Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LIPC | P11150 | 1/20 | 0.48 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.48 |
| ▸ | KDM4C | Q9H3R0 | 3/20 | 0.48 |
| ▸ | CREBBP | Q92793 | 3/20 | 0.47 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ASPH | Q12797 | 1/20 | 0.41 |
| ▸ | RIOX2 | Q8IUF8 | 1/20 | 0.41 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 5/20 | 0.40 |
| ▸ | HSP90AB1 | P08238 | 5/20 | 0.40 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2425635 | 0.86 | HSP90AA1 (0.52) | LIPCLIPGKDM4CCREBBPPTGER4 | |
| SCHEMBL15774700 | 0.77 | PTGER4 (0.67) | LIPCLIPGKDM4CCREBBPPTGER4 | |
| SCHEMBL13450266 | 0.77 | HSP90AA1 (0.51) | LIPCLIPGKDM4CCREBBPPTGER4 | |
| SCHEMBL29673306 | 0.73 | LIPC (0.47) | LIPCLIPGKDM4CCREBBPPTGER4 | |
| SCHEMBL20587134 | 0.73 | LIPC (0.47) | LIPCLIPGKDM4CCREBBPPTGER4 | |
| SCHEMBL3972333 | 0.72 | HSP90AA1 (0.43) | LIPCLIPGCREBBPPTGER4KDM4E | |
| SCHEMBL17371276 | 0.72 | KMT2A (0.49) | LIPCLIPGKDM4CPIM1KMT2A | |
| SCHEMBL13450306 | 0.71 | HSP90AA1 (0.54) | LIPCLIPGCREBBPPTGER4HSP90AA1 | |
| SCHEMBL13451066 | 0.69 | HSP90AA1 (0.65) | CREBBPPTGER4HSP90AA1HSP90AB1 | |
| SCHEMBL194971 | 0.69 | KDM4C (0.63) | LIPCLIPGKDM4CKDM4EASPH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2074120-A1 | TROPANE COMPOUNDS | Exelixis, Inc. (US) | 2009-07-01 | — | — | EP | disclosed |
| WO-2009055077-A1 | TROPANE COMPOUNDS | EXELIXIS, INC. (US) | 2009-04-30 | — | — | WO | disclosed |