Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 1/20 | 0.43 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 4/20 | 0.43 |
| ▸ | DRD3 | P35462 | 4/20 | 0.43 |
| ▸ | CCR3 | P51677 | 4/20 | 0.40 |
| ▸ | NAMPT | P43490 | 1/20 | 0.40 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.40 |
| ▸ | HRH1 | P35367 | 3/20 | 0.40 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.40 |
| ▸ | SSTR5 | P35346 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4071894 | 0.88 | GPR6 (0.40) | DRD2DRD3CCR3HRH1GPR119 | |
| SCHEMBL3966400 | 0.84 | NAMPT (0.44) | HTR7DRD2DRD3CCR3NAMPT | |
| SCHEMBL3079469 | 0.77 | PRKAA2 (0.60) | DRD2DRD3PRKAA2HTR2A | |
| SCHEMBL4081506 | 0.77 | PRKAA2 (0.60) | DRD2DRD3PRKAA2HTR2A | |
| SCHEMBL4057717 | 0.76 | GPR6 (0.42) | DRD2DRD3CCR3HRH1HTR2A | |
| SCHEMBL14715680 | 0.75 | NAMPT (0.48) | HTR7ADRA1BCCR3NAMPTHRH1 | |
| SCHEMBL3969152 | 0.75 | NAMPT (0.48) | HTR7ADRA1BCCR3NAMPTHRH1 | |
| SCHEMBL3963463 | 0.75 | NAMPT (0.48) | HTR7ADRA1BCCR3NAMPTHRH1 | |
| SCHEMBL28779341 | 0.73 | HSD11B1 (0.51) | HTR7HTR2A | |
| SCHEMBL28779340 | 0.73 | HSD11B1 (0.51) | HTR7HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2079693-B1 | ETHER DERIVATIVES DUAL MODULATORS OF THE 5-HT2A AND D3 RECEPTORS | HOFFMANN LA ROCHE (CH) | 2013-02-27 | — | — | EP | claimed |
| EP-2079693-A1 | ETHER DERIVATIVES DUAL MODULATORS OF THE 5-HT2A AND D3 RECEPTORS | F. Hoffmann-Roche AG (CH) | 2009-07-22 | — | — | EP | claimed |
| WO-2008052899-A1 | ETHER DERIVATIVES DUAL MODULATORS OF THE 5-HT2A AND D3 RECEPTORS | F. HOFFMANN-LA ROCHE AG (CH) | 2008-05-08 | — | — | WO | claimed |