Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 4/20 | 0.65 |
| ▸ | CYP4F2 | P78329 | 3/20 | 0.63 |
| ▸ | CYP4A11 | Q02928 | 3/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | DDX3X | O00571 | 1/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.47 |
| ▸ | POLQ | O75417 | 1/20 | 0.47 |
| ▸ | PPARG | P37231 | 2/20 | 0.46 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.45 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.45 |
| ▸ | MAOA | P21397 | 1/20 | 0.45 |
| ▸ | MAOB | P27338 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20080059 | 0.90 | CYP4F2 (0.61) | EPHX2CYP4F2CYP4A11KDM4EALDH1A1 | |
| SCHEMBL28008267 | 0.86 | CYP4F2 (0.65) | EPHX2CYP4F2CYP4A11KDM4EALDH1A1 | |
| SCHEMBL27151696 | 0.86 | EPHX2 (0.54) | EPHX2CYP4F2CYP4A11KDM4EALDH1A1 | |
| SCHEMBL3801344 | 0.84 | POLQ (0.56) | EPHX2CYP4F2CYP4A11KDM4EALDH1A1 | |
| SCHEMBL21015416 | 0.84 | EPHX2 (0.51) | EPHX2KDM4EALDH1A1GAAPOLQ | |
| SCHEMBL69660 | 0.84 | CYP4F2 (0.86) | EPHX2CYP4F2CYP4A11KDM4EALDH1A1 | |
| SCHEMBL16269238 | 0.82 | EPHX2 (0.61) | EPHX2CYP4F2CYP4A11KDM4EALDH1A1 | |
| SCHEMBL5990285 | 0.81 | CYP4F2 (0.48) | EPHX2CYP4F2CYP4A11KDM4EALDH1A1 | |
| SCHEMBL15936212 | 0.81 | CYP4F2 (0.48) | EPHX2CYP4F2CYP4A11ALDH1A1GAA | |
| SCHEMBL28008696 | 0.80 | CYP4F2 (0.81) | EPHX2CYP4F2CYP4A11KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1847533-B1 | SIX-MEMBERED HETEROCYCLIC COMPOUND AND THE USE THEREOF | ASAHI KASEI PHARMA CORP (JP) | 2013-08-14 | — | — | EP | disclosed |
| CN-101133037-B | Six-membered heterocyclic compound and use thereof | ASAHI KASEI PHARMA CORP | 2012-05-09 | — | — | CN | disclosed |
| US-7531533-B2 | 6-Membered heterocyclic compound and use thereof | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-05-12 | — | — | US | disclosed |
| EP-1847533-A1 | SIX-MEMBERED HETEROCYCLIC COMPOUND AND THE USE THEREOF | Asahi Kasei Pharma Corporation (JP) | 2007-10-24 | — | — | EP | disclosed |
| US-20070060590-A1 | 6-Membered heterocyclic compound and use thereof | ASAHI KASEI PHARMA CORPORATION (JP) | 2007-03-15 | — | — | US | disclosed |
| US-6911468-B2 | Tyrosine phosphatase inhibitors | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2005-06-28 | — | — | US | disclosed |
| US-20030144338-A1 | Tyrosine phosphatase inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2003-07-31 | — | — | US | disclosed |
| EP-1284260-A1 | TYROSINE PHOSPHATASE INHIBITORS | Takeda Chemical Industries, Ltd. (JP) | 2003-02-19 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030144338-A1 | Tyrosine phosphatase inhibitors | PTPRC, PTPN1, PTPRM | EPHX2 2965/4885CYP4F2 1593/4885CYP4A11 1052/4885 |
| US-20070060590-A1 | 6-Membered heterocyclic compound and use thereof | WNT1, CYP11B2, CYP11B1 | EPHX2 2324/4885CYP4F2 781/4885CYP4A11 56/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.