Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 5/20 | 0.52 |
| ▸ | OPRK1 | P41145 | 5/20 | 0.52 |
| ▸ | OPRD1 | P41143 | 4/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.47 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.41 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.41 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | F3 | P13726 | 1/20 | 0.37 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | PTAFR | P25105 | 1/20 | 0.36 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.36 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.36 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4073644 | 0.87 | OPRM1 (0.53) | OPRM1OPRK1OPRD1HDAC1ITGB1 | |
| SCHEMBL4496256 | 0.86 | OPRM1 (0.52) | OPRM1OPRK1OPRD1HDAC1ITGB1 | |
| Hydrochloric Acid SCHEMBL4073979 | 0.86 | OPRM1 (0.52) | OPRM1OPRK1OPRD1HDAC1ITGB1 | |
| SCHEMBL1345547 | 0.80 | HDAC1 (0.58) | OPRM1OPRK1OPRD1HDAC1CA2 | |
| SCHEMBL4075641 | 0.80 | OPRM1 (0.52) | OPRM1OPRK1OPRD1HDAC1CA2 | |
| Hydrochloric Acid SCHEMBL4475141 | 0.79 | OPRM1 (0.51) | OPRM1OPRK1OPRD1HDAC1CA2 | |
| SCHEMBL4083769 | 0.76 | OPRM1 (0.42) | OPRM1OPRK1OPRD1HDAC1ITGB1 | |
| SCHEMBL4249213 | 0.76 | OPRM1 (0.48) | OPRM1OPRK1OPRD1HDAC1SLC6A2 | |
| SCHEMBL4080426 | 0.75 | OPRM1 (0.48) | OPRM1OPRK1OPRD1HDAC1ITGB1 | |
| SCHEMBL1347921 | 0.75 | OPRM1 (0.46) | OPRM1OPRK1OPRD1HDAC1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7615651-B2 | Diaryl, dipyridinyl and aryl-pyridinyl derivatives and uses thereof | PFIZER INC. (US) | 2009-11-10 | — | — | US | claimed |
| EP-2084127-A1 | DIARYL, DIPYRIDINYL AND ARYL-PYRIDINYL DERIVATIVES AND USES THEREOF | Pfizer Products Inc. (US) | 2009-08-05 | — | — | EP | claimed |
| WO-2008059335-A1 | DIARYL, DIPYRIDINYL AND ARYL-PYRIDINYL DERIVATIVES AND USES THEREOF | PFIZER PRODUCTS INC. (US) | 2008-05-22 | — | — | WO | claimed |