Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 3/20 | 0.52 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.52 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.47 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.43 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.43 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.41 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.39 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.39 |
| ▸ | DPP4 | P27487 | 1/20 | 0.39 |
| ▸ | RORC | P51449 | 1/20 | 0.38 |
| ▸ | DGAT1 | O75907 | 2/20 | 0.38 |
| ▸ | SOAT1 | P35610 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4073644 | 0.87 | OPRM1 (0.53) | OPRM1OPRK1OPRD1HDAC1ITGB1 | |
| SCHEMBL4080426 | 0.86 | OPRM1 (0.48) | OPRM1OPRK1OPRD1HDAC1ITGB1 | |
| Hydrochloric Acid SCHEMBL4073979 | 0.86 | OPRM1 (0.52) | OPRM1OPRK1OPRD1HDAC1ITGB1 | |
| SCHEMBL4081703 | 0.86 | OPRM1 (0.52) | OPRM1OPRK1OPRD1HDAC1ITGB1 | |
| SCHEMBL4075483 | 0.84 | OPRK1 (0.39) | OPRM1OPRK1OPRD1HDAC1ITGB1 | |
| SCHEMBL4253659 | 0.83 | OPRM1 (0.46) | OPRM1OPRK1OPRD1HDAC1ITGB1 | |
| SCHEMBL27764621 | 0.81 | OPRM1 (0.45) | OPRM1OPRK1OPRD1HDAC1ITGB1 | |
| SCHEMBL3693713 | 0.81 | OPRK1 (0.49) | OPRM1OPRK1OPRD1SLC6A2SLC6A4 | |
| SCHEMBL1345547 | 0.80 | HDAC1 (0.58) | OPRM1OPRK1OPRD1HDAC1SMN1; SMN2 | |
| SCHEMBL4075641 | 0.80 | OPRM1 (0.52) | OPRM1OPRK1OPRD1HDAC1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7615651-B2 | Diaryl, dipyridinyl and aryl-pyridinyl derivatives and uses thereof | PFIZER INC. (US) | 2009-11-10 | — | — | US | claimed |
| EP-2084127-A1 | DIARYL, DIPYRIDINYL AND ARYL-PYRIDINYL DERIVATIVES AND USES THEREOF | Pfizer Products Inc. (US) | 2009-08-05 | — | — | EP | claimed |
| WO-2008059335-A1 | DIARYL, DIPYRIDINYL AND ARYL-PYRIDINYL DERIVATIVES AND USES THEREOF | PFIZER PRODUCTS INC. (US) | 2008-05-22 | — | — | WO | claimed |