R-Fenoprofen

R-Fenoprofen

SCHEMBL4082

C[C@@H](C(=O)O)c1cccc(Oc2ccccc2)c1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

PTGS1PTGS2

The experimentally established mechanism targets of R-Fenoprofen. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PTGS1 known ✓ P23219 5/20 1.00
PTGS2 known ✓ P35354 5/20 0.58
MEN1 O00255 1/20 0.72
CYP2D6 P10635 1/20 0.72
KMT2A Q03164 1/20 0.72
ALOX5 P09917 1/20 0.60
FFAR1 O14842 1/20 0.59
MAPT P10636 2/20 0.58
CXCR1 P25024 2/20 0.58
CXCR2 P25025 2/20 0.58
SMN1; SMN2 Q16637 2/20 0.58
SLC22A6 Q4U2R8 2/20 0.58
RECQL P46063 1/20 0.58
KDM4E B2RXH2 1/20 0.58
ALDH1A1 P00352 1/20 0.58
LMNA P02545 1/20 0.58
CYP3A4 P08684 1/20 0.58
HPGD P15428 1/20 0.58
MAPK1 P28482 1/20 0.58
PMP22 Q01453 1/20 0.58

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
(S)-Fenoprofen SCHEMBL4492279 1.00 PTGS1 (1.00) PTGS1MEN1CYP2D6KMT2AALOX5
Fenoprofen SCHEMBL11336376 1.00 PTGS1 (1.00) PTGS1MEN1CYP2D6KMT2AALOX5
Fenoprofen SCHEMBL29481372 1.00 PTGS1 (1.00) PTGS1MEN1CYP2D6KMT2AALOX5
R-Fenoprofen SCHEMBL30910976 1.00 PTGS1 (1.00) PTGS1MEN1CYP2D6KMT2AALOX5
Fenoprofen SCHEMBL8754928 1.00 PTGS1 (1.00) PTGS1MEN1CYP2D6KMT2AALOX5
Fenoprofen SCHEMBL3797 1.00 PTGS1 (1.00) PTGS1MEN1CYP2D6KMT2AALOX5
Fenoprofen SCHEMBL4081 0.98 PTGS1 (0.97) PTGS1MEN1CYP2D6KMT2AALOX5
Fenoprofen SCHEMBL8706502 0.98 PTGS1 (0.97) PTGS1MEN1CYP2D6KMT2AALOX5
Fenoprofen SCHEMBL11125651 0.98 PTGS1 (0.97) PTGS1MEN1CYP2D6KMT2AALOX5
Fenoprofen SCHEMBL5108677 0.97 PTGS1 (0.94) PTGS1MEN1CYP2D6KMT2AALOX5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 8290 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4701663-A1 PROLYL HYDROXYLASE DOMAIN-CONTAINING PROTEIN (PHD) INHIBITORS, COMBINATIONS AND USES THEREOF Insilico Medicine IP Limited (HK) 2026-03-04 EP claimed
US-20260041660-A1 Compositions And Methods for Treating Acute Respiratory Distress Syndrome (ARDS) And Inflammatory Disorders Caused by Corona Viruses and Other Respiratory Pathogens or Agents That Mediate Pulmonary Injury, Inflammation or Acute Respiratory Distress, And Related Compositions and Methods for Treating and Preventing Human SARS Coronavirus Infection, COVID-19 Disease and Related Symptoms CHANG RICHARD L (US) 2026-02-12 US claimed
EP-4662203-A1 BINDARIT CONJUGATES, COMPOSITIONS AND METHODS FOR TREATING OCULAR DISEASES OR DISORDERS Translatum Medicus Inc. (CA) 2025-12-17 EP claimed
EP-4615506-A1 USE OF GSK-3 ACTIVATIOR TO MODULATE PROTEASOME ACTIVITY TO PREVENT AGEING ASSOCIATED CONDITIONS AND DISEASES Sahin, Fikret (TR) 2025-09-17 EP claimed
WO-2025132620-A1 STABLE SOFT CAPSULE PREPARATIONS WITH SOLID FILL FOR MOISTURE SENSITIVE ACTIVE INGREDIENTS BAYER CONSUMER CARE AG (CH) 2025-06-26 WO claimed
CN-119757554-A High performance liquid chromatography-tandem mass spectrometry analysis method for simultaneously detecting 33 components of anti-inflammatory agent in cosmetics 四川省药品检验研究院(四川省医疗器械检测中心) 2025-04-04 CN claimed
US-20250099590-A1 HIGH DENSITY ULTRASOUND COUPLING GEL AND METHODS OF USE THEREOF ZETROZ SYSTEMS LLC (US) 2025-03-27 US claimed
CN-119591490-A Preparation method of fenoprofen and preparation method of fenoprofen calcium 康普药业股份有限公司 2025-03-11 CN claimed
US-20250032503-A1 USE OF APREPITANT FOR TREATING ALZHEIMER'S DISEASE HOTH THERAPEUTICS, INC. 2025-01-30 US claimed
WO-2024258363-A1 USE OF GSK-3 ACTIVATIOR TO MODULATE PROTEASOME ACTIVITY TO PREVENT AGEING ASSOCIATED CONDITIONS AND DISEASES SAHIN FIKRET (TR) 2024-12-19 WO claimed
EP-0225005-B1 ANTI-INFLAMMATORY ANALGESIC ADHESIVE PREPARATION NITTO DENKO CORPORATION (JP) 1990-03-14 EP claimed
EP-0271489-B1 THERAPEUTIC COMPOSITION BLASS, David Henry (GB) 1990-02-28 EP claimed
US-4867985-A CONTROLLED RELEASE OF NON-STEROID ANTIINFLAMMATORY AGENTS EUROCELTIQUE S.A. (LU) 1989-09-19 US claimed
US-4753801-A DRUGS, LOW WATER SOLUBILITY ELI LILLY AND COMPANY (US) 1988-06-28 US claimed
EP-0225005-A1 Anti-inflammatory analgesic adhesive preparation NITTO DENKO CORPORATION (JP) 1987-06-10 EP claimed
EP-0221732-A2 Sustained release tablets ELI LILLY AND COMPANY (US) 1987-05-13 EP claimed
US-4599359-A POTENTIATION Cooper, Stephen A. (US) 1986-07-08 US claimed
EP-0174006-A2 Antidiarrheal compositions and use thereof Richardson-Vicks, Inc. (US) 1986-03-12 EP claimed
WO-1984002273-A1 ANALGESIC COMBINATIONS SANDOZ AG (CH) 1984-06-21 WO claimed
EP-0111456-A1 Analgesic combinations Cooper, Stephen A. Dr. (US) 1984-06-20 EP claimed