Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Fenoprofen. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 known ✓ | P23219 | 5/20 | 0.97 |
| ▸ | PTGS2 known ✓ | P35354 | 5/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.70 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.70 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.58 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | CXCR1 | P25024 | 2/20 | 0.57 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | SLC22A6 | Q4U2R8 | 2/20 | 0.57 |
| ▸ | RECQL | P46063 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.57 |
| ▸ | HPGD | P15428 | 1/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fenoprofen SCHEMBL4081 | 1.00 | PTGS1 (0.97) | PTGS1MEN1CYP2D6KMT2AALOX5 | |
| Fenoprofen SCHEMBL6269014 | 0.98 | PTGS1 (0.94) | PTGS1MEN1CYP2D6KMT2AALOX5 | |
| Fenoprofen SCHEMBL435081 | 0.98 | PTGS1 (0.94) | PTGS1MEN1CYP2D6KMT2AALOX5 | |
| Fenoprofen SCHEMBL5108677 | 0.98 | PTGS1 (0.94) | PTGS1MEN1CYP2D6KMT2AALOX5 | |
| Fenoprofen SCHEMBL11336376 | 0.98 | PTGS1 (1.00) | PTGS1MEN1CYP2D6KMT2AALOX5 | |
| Fenoprofen SCHEMBL3797 | 0.98 | PTGS1 (1.00) | PTGS1MEN1CYP2D6KMT2AALOX5 | |
| Fenoprofen SCHEMBL8754928 | 0.98 | PTGS1 (1.00) | PTGS1MEN1CYP2D6KMT2AALOX5 | |
| R-Fenoprofen SCHEMBL4082 | 0.98 | PTGS1 (1.00) | PTGS1MEN1CYP2D6KMT2AALOX5 | |
| (S)-Fenoprofen SCHEMBL4492279 | 0.98 | PTGS1 (1.00) | PTGS1MEN1CYP2D6KMT2AALOX5 | |
| R-Fenoprofen SCHEMBL30910976 | 0.98 | PTGS1 (1.00) | PTGS1MEN1CYP2D6KMT2AALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0805684-A4 | METHODS OF ENHANCING THE THERAPEUTIC ACTIVITY OF NSAIDS AND COMPOSITIONS OF ZWITTERIONIC PHOSPHOLIPIDS USEFUL THEREIN | UNIV TEXAS (US) | 1998-08-05 | — | — | EP | disclosed |
| WO-1998013073-A1 | METHODS OF ENHANCING THE THERAPEUTIC ACTIVITY OF NSAIDs AND COMPOSITIONS OF ZWITTERIONIC PHOSPHOLIPIDS USEFUL THEREIN | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 1998-04-02 | — | — | WO | disclosed |
| EP-0805684-A2 | METHODS OF ENHANCING THE THERAPEUTIC ACTIVITY OF NSAIDS AND COMPOSITIONS OF ZWITTERIONIC PHOSPHOLIPIDS USEFUL THEREIN | THE BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 1997-11-12 | — | — | EP | disclosed |
| WO-1996022780-A1 | METHODS OF ENHANCING THE THERAPEUTIC ACTIVITY OF NSAIDS AND COMPOSITIONS OF ZWITTERIONIC PHOSPHOLIPIDS USEFUL THEREIN | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 1996-08-01 | — | — | WO | disclosed |