Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 4/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | NPFFR1 | Q9GZQ6 | 1/20 | 0.35 |
| ▸ | NPFFR2 | Q9Y5X5 | 1/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.34 |
| ▸ | TACR1 | P25103 | 2/20 | 0.34 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | DPP4 | P27487 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.33 |
| ▸ | KDM1A | O60341 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9954933 | 0.82 | DPP4 (0.44) | CYP3A4TSHRNPFFR1NPFFR2P2RX7 | |
| SCHEMBL1586715 | 0.81 | TACR1 (0.42) | CYP3A4CYP2D6TSHRALDH1A1CYP2C9 | |
| SCHEMBL15824244 | 0.81 | DPP4 (0.43) | CYP3A4TSHRALDH1A1NPFFR1NPFFR2 | |
| SCHEMBL7500962 | 0.76 | CYP3A4 (0.43) | CYP3A4CYP2D6TSHRUSP2ALDH1A1 | |
| SCHEMBL17829153 | 0.73 | NPFFR1 (0.35) | CYP3A4TSHRALDH1A1NPFFR1NPFFR2 | |
| SCHEMBL1187758 | 0.73 | IDO1 (0.39) | CYP3A4CYP2D6TSHRCYP2C9NPFFR1 | |
| SCHEMBL14999534 | 0.72 | IDO1 (0.38) | CYP3A4CYP2D6TSHRUSP2ALDH1A1 | |
| SCHEMBL27777487 | 0.71 | MMP8 (0.42) | CYP3A4CYP2D6TSHRCYP2C9NPFFR1 | |
| SCHEMBL77054 | 0.71 | IDO1 (0.41) | CYP3A4CYP2D6TSHRALDH1A1CYP2C9 | |
| SCHEMBL15928065 | 0.71 | IDO1 (0.39) | CYP3A4CYP2D6TSHRHTR2ACXCR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2104665-A2 | IMIDAZOLONE AND IMIDAZOLIDINONE DERIVATIVES AS 11B-HSD1 INHIBITORS FOR DIABETES | F. Hoffmann-Roche AG (CH) | 2009-09-30 | — | — | EP | disclosed |
| WO-2008046758-A2 | IMIDAZOLONE AND IMIDAZOLIDINONE DERIVATIVES AS 11B-HSD1 INHIBITORS FOR DIABETES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-04-24 | — | — | WO | disclosed |