Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 10/20 | 0.69 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.51 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.47 |
| ▸ | CLK1 | P49759 | 1/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.46 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.46 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.46 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.46 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.46 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.45 |
| ▸ | BCHE | P06276 | 1/20 | 0.44 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1892231 | 0.91 | HDAC1 (0.85) | HDAC1CLK1HDAC3HDAC4HDAC7 | |
| SCHEMBL1885626 | 0.87 | HDAC1 (0.87) | HDAC1CLK1HDAC3HDAC4HDAC7 | |
| SCHEMBL1888083 | 0.82 | HDAC1 (1.00) | HDAC1CLK1HDAC3HDAC4HDAC7 | |
| SCHEMBL4255241 | 0.81 | HDAC1 (0.82) | HDAC1BCL2L1TBXAS1 | |
| SCHEMBL1890182 | 0.78 | HDAC1 (0.87) | HDAC1HDAC3HDAC4HDAC7HDAC2 | |
| SCHEMBL1890935 | 0.76 | HDAC1 (1.00) | HDAC1CLK1HDAC3HDAC4HDAC7 | |
| SCHEMBL5808344 | 0.74 | HDAC1 (0.61) | HDAC1HDAC3HDAC4HDAC7HDAC2 | |
| SCHEMBL15638889 | 0.74 | SIGMAR1 (0.72) | HDAC1SIGMAR1HDAC3HDAC4HDAC7 | |
| SCHEMBL14449034 | 0.74 | HDAC1 (0.83) | HDAC1CLK1 | |
| SCHEMBL1886196 | 0.72 | HDAC1 (1.00) | HDAC1HDAC3HDAC4HDAC7HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1677731-A4 | THIOPHENE AND BENZOTHIOPHENE HYDROXAMIC ACID DERIVATIVES | ATON PHARMA INC (US) | 2009-05-06 | — | — | EP | claimed |
| EP-1677731-A2 | THIOPHENE AND BENZOTHIOPHENE HYDROXAMIC ACID DERIVATIVES | Aton Pharma, Inc. (US) | 2006-07-12 | — | — | EP | claimed |
| WO-2005034880-A2 | THIOPHENE AND BENZOTHIOPHENE HYDROXAMIC ACID DERIVATIVES | ATON PHARMA, INC. (US) | 2005-04-21 | — | — | WO | claimed |