Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | ATF4 | P18848 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL206154 | 0.85 | TSHR (0.46) | LMNAKMT2AATMHPGDPOLB | |
| SCHEMBL208300 | 0.82 | LMNA (0.50) | LMNAKMT2APOLBTSHREPHX1 | |
| SCHEMBL206987 | 0.82 | POLB (0.56) | MAPTLMNAKMT2AHPGDPOLB | |
| SCHEMBL206704 | 0.80 | SMYD3 (0.39) | MAPTKMT2AHPGDPOLBL3MBTL1 | |
| SCHEMBL206071 | 0.80 | CNR1 (0.52) | LMNAKMT2AHPGDPOLBEPHX1 | |
| SCHEMBL2989386 | 0.79 | LMNA (0.45) | MAPTLMNAHPGDPOLBEPHX1 | |
| SCHEMBL207560 | 0.79 | POLB (0.41) | MAPTLMNAKMT2AHPGDPOLB | |
| SCHEMBL206304 | 0.78 | CNR1 (0.44) | LMNAKMT2AL3MBTL1EPHX1 | |
| SCHEMBL2986952 | 0.78 | MEN1 (0.47) | LMNAKMT2AATF4 | |
| SCHEMBL206988 | 0.78 | ALDH1A1 (0.51) | MAPTLMNAKMT2AHPGDTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1745010-B1 | SUBSTITUTED CYCLOHEXYL-1,4-DIAMINE DERIVATIVES | GRUENENTHAL GMBH (DE) | 2009-08-05 | — | — | EP | claimed |