Hydrochloric Acid

Hydrochloric Acid

SCHEMBL4084423

[Cl-].[Cl-].[Zr+2]C1C=Cc2c1ccc1ccccc21

nearest known ligand 0.39

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Known targets — ChEMBL curated mechanism

ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA

The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 6/20 0.39
CYP2A6 P11509 5/20 0.39
HSD17B10 Q99714 4/20 0.39
TSHR P16473 3/20 0.39
TDP1 Q9NUW8 1/20 0.39
HPRT1 P00492 1/20 0.37
CYP1A2 P05177 4/20 0.34
HPGD P15428 2/20 0.34
HIF1A Q16665 1/20 0.34
CYP1B1 Q16678 1/20 0.34
THRB P10828 1/20 0.34
KDM1A O60341 1/20 0.34
CYP3A4 P08684 3/20 0.33
LMNA P02545 2/20 0.33
MAPK1 P28482 2/20 0.33
KEAP1 Q14145 1/20 0.33
CA12 O43570 1/20 0.33
CA9 Q16790 1/20 0.33
MAPT P10636 1/20 0.33
APEX1 P27695 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL7807228 0.83 ALDH1A1 (0.35) ALDH1A1HSD17B10HPGDKDM1ALMNA
Hydrochloric Acid SCHEMBL4067077 0.78 ALDH1A1 (0.39) ALDH1A1CYP2A6HSD17B10TSHRTDP1
Hydrochloric Acid SCHEMBL4083401 0.78 ALDH1A1 (0.39) ALDH1A1CYP2A6HSD17B10TSHRTDP1
Hydrochloric Acid SCHEMBL6230006 0.76 ALDH1A1 (0.38) ALDH1A1CYP2A6HSD17B10TSHRTDP1
SCHEMBL5702772 0.76 ALDH1A1 (0.41) ALDH1A1CYP2A6HSD17B10TSHRTDP1
SCHEMBL5862935 0.76 ALDH1A1 (0.41) ALDH1A1CYP2A6HSD17B10TSHRTDP1
SCHEMBL9245394 0.76 ALDH1A1 (0.41) ALDH1A1CYP2A6HSD17B10TSHRTDP1
SCHEMBL5859155 0.76 ALDH1A1 (0.41) ALDH1A1CYP2A6HSD17B10TSHRTDP1
SCHEMBL27567037 0.73 ALDH1A1 (0.38) ALDH1A1CYP2A6HSD17B10TSHRTDP1
SCHEMBL9789622 0.73 ALDH1A1 (0.38) ALDH1A1CYP2A6HSD17B10TSHRTDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-106459246-B Process for producing olefin polymer, catalyst for olefin polymerization, and olefin polymer 出光兴产株式会社 2020-04-10 CN disclosed
US-20180273669-A1 CROSS-COPOLYMER AND METHOD FOR PRODUCING SAME DENKA COMPANY LIMITED (JP) 2018-09-27 US disclosed
WO-2009104782-A1 ETHYLENE HOMOPOLYMER SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2009-08-27 WO disclosed
WO-2009104783-A1 CATALYST COMPONENT FOR POLYMERIZATION OF ETHYLENE AND PROCESS FOR PRODUCING ETHYLENE POLYMER (2) SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2009-08-27 WO disclosed
WO-2009104785-A1 CATALYST COMPONENT FOR POLYMERIZATION OF ETHYLENE AND PROCESS FOR PRODUCING ETHYLENE POLYMER (1) SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2009-08-27 WO disclosed
EP-1865006-B1 Propylene polymer and composition containing the same, molded object and laminate comprising these, and processes for producing propylene polymer and composition containing the same IDEMITSU KOSAN CO (JP) 2009-06-24 EP disclosed
US-7459503-B2 modified by organic acid such as maleic anhydride, acrylic acid, or an alkyl acrylate; increased compatibility with an inorganic filler; high-adhesive sealant IDEMITSU KOSAN CO., LTD. (JP) 2008-12-02 US disclosed
EP-1195386-B1 TRANSITION METAL CATALYST COMPONENT FOR POLYMERIZATION AND PROCESS FOR PRODUCING POLYMER WITH THE SAME DENKI KAGAKU KOGYO KK (JP) 2007-06-20 EP disclosed
EP-1041092-B1 ETHYLENE/AROMATIC VINYL COPOLYMER AND PROCESS FOR PRODUCING THE SAME DENKI KAGAKU KOGYO KK (JP) 2005-11-02 EP disclosed
EP-0818458-B1 TRANSITION METAL COMPOUND, POLYMERIZATION CATALYST FOR OLEFINS, AND PROCESS FOR PRODUCING OLEFINIC POLYMERS IDEMITSU KOSAN CO (JP) 2004-02-25 EP disclosed
US-6433083-B2 MOLDING MATERIAL; HEAT AND SOLVENT RESISTANCE, TOUGHNESS, TENSILE STRENGTH, ELONGATION, TRANSPARENT IDEMITSU PETROCHEMICAL CO., LTD. (JP) 2002-08-13 US disclosed
US-6410673-B1 MOLDING MATERIALS DENKI KAGAKU KOGYO KABUSHIKI KAISHA (JP) 2002-06-25 US disclosed
US-20010025085-A1 Aromatic vinyl resin material and molded products thereof IDEMITSU PETROCHEMICAL CO., LTD. (JP) 2001-09-27 US disclosed
US-6207753-B1 RESIN MATERIALS FOR PRODUCING MOLDED PRODUCTS ENDOWED WITH EXCELLENT HEAT RESISTANCE, SOLVENT RESISTANCE, TOUGHNESS, TENSILE ELONGATION AND TRANSPARENCY IDEMITSU PETROCHEMICAL CO., LTD. (JP) 2001-03-27 US disclosed
EP-1041092-A1 ETHYLENE/AROMATIC VINYL COPOLYMER AND PROCESS FOR PRODUCING THE SAME DENKI KAGAKU KOGYO KABUSHIKI KAISHA (JP) 2000-10-04 EP disclosed
US-5830821-A POLYMERIZATION CATALYST TARGOR GMBH (DE) 1998-11-03 US disclosed
US-5455366-A Olefin polymerization catalysts HOECHST AG (DE) 1995-10-03 US disclosed