Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 5/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.37 |
| ▸ | SSTR2 | P30874 | 1/20 | 0.37 |
| ▸ | DHODH | Q02127 | 6/20 | 0.37 |
| ▸ | PARP1 | P09874 | 3/20 | 0.37 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.34 |
| ▸ | ESR1 | P03372 | 1/20 | 0.34 |
| ▸ | ATR | Q13535 | 1/20 | 0.34 |
| ▸ | TNKS | O95271 | 1/20 | 0.33 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.33 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4087266 | 0.72 | HRH4 (0.44) | HRH4PARP1ATR | |
| SCHEMBL3476911 | 0.71 | HRH4 (0.56) | HRH4DHODHCARM1 | |
| SCHEMBL4078500 | 0.70 | HRH4 (0.43) | HRH4PARP1 | |
| SCHEMBL3477078 | 0.67 | HRH4 (0.67) | HRH4KCNH2SSTR2DHODHPARP1 | |
| SCHEMBL602241 | 0.67 | HRH4 (0.45) | HRH4KCNH2SSTR2DHODHPARP1 | |
| SCHEMBL3476444 | 0.67 | HRH4 (0.55) | HRH4KCNH2SSTR2DHODHPARP1 | |
| SCHEMBL3476442 | 0.66 | HRH4 (0.61) | HRH4KCNH2SSTR2DHODHPARP1 | |
| SCHEMBL3477289 | 0.66 | HRH4 (0.45) | HRH4KCNH2PARP1 | |
| SCHEMBL31474773 | 0.66 | RPS6KA3 (0.56) | DHODHPARP1RPS6KA3TNKSTNKS2 | |
| SCHEMBL4080120 | 0.66 | PARP1 (0.41) | HRH4KCNH2PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2009532367-A | — | — | 2009-09-10 | — | — | JP | claimed |
| EP-2004188-A4 | BENZOIMIDAZOL-2-YL PYRIDINES AS MODULATORS OF THE HISTAMINE H4 RECEPTOR | JANSSEN PHARMACEUTICA NV (BE) | 2009-04-22 | — | — | EP | claimed |
| EP-2004188-A2 | BENZOIMIDAZOL-2-YL PYRIDINES AS MODULATORS OF THE HISTAMINE H4 RECEPTOR | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-12-24 | — | — | EP | claimed |
| WO-2007117400-A2 | BENZOIMIDAZOL-2-YL PYRIDINES AS MODULATORS OF THE HISTAMINE H4 RECEPTOR | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-10-18 | — | — | WO | claimed |