Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Aspartic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIK1 | P39086 | 5/20 | 0.54 |
| ▸ | GRIK2 | Q13002 | 3/20 | 0.54 |
| ▸ | GRM1 | Q13255 | 2/20 | 0.54 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.54 |
| ▸ | SLC1A1 | P43005 | 4/20 | 0.52 |
| ▸ | SLC1A3 | P43003 | 3/20 | 0.52 |
| ▸ | SLC1A2 | P43004 | 3/20 | 0.52 |
| ▸ | GRIA4 | P48058 | 2/20 | 0.52 |
| ▸ | GRIK3 | Q13003 | 2/20 | 0.52 |
| ▸ | GRIK5 | Q16478 | 2/20 | 0.52 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.52 |
| ▸ | GRM8 | O00222 | 1/20 | 0.52 |
| ▸ | GRM6 | O15303 | 1/20 | 0.52 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.52 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.52 |
| ▸ | GSR | P00390 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | GRM5 | P41594 | 1/20 | 0.52 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.52 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Aspartic Acid SCHEMBL11089941 | 1.00 | GRIK1 (0.54) | GRIK1GRIK2GRM1GRM2SLC1A1 | |
| Aspartic Acid SCHEMBL1085707 | 1.00 | GRIK1 (0.54) | GRIK1GRIK2GRM1GRM2SLC1A1 | |
| Aspartic Acid SCHEMBL4084806 | 1.00 | GRIK1 (0.54) | GRIK1GRIK2GRM1GRM2SLC1A1 | |
| Aspartic Acid SCHEMBL11089943 | 1.00 | GRIK1 (0.54) | GRIK1GRIK2GRM1GRM2SLC1A1 | |
| Aspartic Acid SCHEMBL1085708 | 1.00 | GRIK1 (0.54) | GRIK1GRIK2GRM1GRM2SLC1A1 | |
| Aspartic Acid SCHEMBL23322528 | 0.97 | GRIK1 (0.52) | GRIK1GRIK2GRM1GRM2SLC1A1 | |
| Aspartic Acid SCHEMBL5195839 | 0.97 | GRIK1 (0.52) | GRIK1GRIK2GRM1GRM2SLC1A1 | |
| Aspartic Acid SCHEMBL5160184 | 0.97 | GRIK1 (0.52) | GRIK1GRIK2GRM1GRM2SLC1A1 | |
| Aspartic Acid SCHEMBL317388 | 0.97 | GRIK1 (0.52) | GRIK1GRIK2GRM1GRM2SLC1A1 | |
| Aspartic Acid SCHEMBL10543254 | 0.97 | GRIK1 (0.52) | GRIK1GRIK2GRM1GRM2SLC1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104610195-B | The aspartate of Vortioxetine or its hydrate and its production and use | 上虞京新药业有限公司 | 2017-06-27 | — | — | CN | claimed |
| CN-104610195-A | Aspartate of vortioxetine or hydrate thereof as well as preparation method and application thereof | SHANGYU JINGXINN PHARMACEUTICAL CO LTD | 2015-05-13 | — | — | CN | claimed |
| US-20220119821-A1 | RECOMBINANT HOST CELLS AND METHODS FOR THE PRODUCTION OF ASPARTIC ACID AND B-ALANINE | UNITED STATES DEPARTMENT OF ENERGY | 2022-04-21 | — | — | US | disclosed |
| CN-113039281-A | Recombinant host cells and methods for producing aspartic acid and beta-alanine | 利戈斯股份有限公司 | 2021-06-25 | — | — | CN | disclosed |
| EP-3810786-A1 | RECOMBINANT HOST CELLS AND METHODS FOR THE PRODUCTION OF ASPARTIC ACID AND BETA-ALANINE | Lygos, Inc. (US) | 2021-04-28 | — | — | EP | disclosed |
| CN-104610195-B | The aspartate of Vortioxetine or its hydrate and its production and use | 上虞京新药业有限公司 | 2017-06-27 | — | — | CN | disclosed |
| CN-104610195-A | Aspartate of vortioxetine or hydrate thereof as well as preparation method and application thereof | SHANGYU JINGXINN PHARMACEUTICAL CO LTD | 2015-05-13 | — | — | CN | disclosed |
| EP-2065075-A1 | Water-in-oil emulsion composition and cosmetic emulsion comprising the same | Shiseido Company, Ltd. (JP) | 2009-06-03 | — | — | EP | disclosed |
| US-20050118211-A1 | Water-in-oil emulsion composition and emulsion cosmetic comprising the same | SHISEIDO COMPANY, LTD. (JP) | 2005-06-02 | — | — | US | disclosed |
| EP-1475070-A1 | WATER-IN-OIL EMULSION COMPOSITION AND EMULSION COSMETIC COMPRISING THE SAME | SHISEIDO COMPANY, LTD. (JP) | 2004-11-10 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050118211-A1 | Water-in-oil emulsion composition and emulsion cosmetic comprising the same | CUTA, LIPA, LRBA | GRIK1 2372/4885GRIK2 2213/4885GRM1 3807/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.