Aspartic Acid

Aspartic Acid

SCHEMBL317388

NC(CC(=O)O)C(=O)O.O.[NaH]

nearest known ligand 0.52

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

SLC6A2SLC6A3

The experimentally established mechanism targets of Aspartic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GRIK1 P39086 7/20 0.52
GRIK2 Q13002 5/20 0.52
GRM1 Q13255 2/20 0.52
GRM2 Q14416 2/20 0.52
SLC1A1 P43005 4/20 0.50
SLC1A3 P43003 3/20 0.50
SLC1A2 P43004 3/20 0.50
GRIA4 P48058 2/20 0.50
GRIK3 Q13003 2/20 0.50
GRIK5 Q16478 2/20 0.50
SLC7A5 Q01650 1/20 0.50
GRM8 O00222 1/20 0.50
GRM6 O15303 1/20 0.50
GRIN2D O15399 1/20 0.50
GRIN3B O60391 1/20 0.50
GSR P00390 1/20 0.50
CYP1A2 P05177 1/20 0.50
GRM5 P41594 1/20 0.50
GRIA1 P42261 1/20 0.50
GRIA2 P42262 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Aspartic Acid SCHEMBL1680010 1.00 GRIK1 (0.52) GRIK1GRIK2GRM1GRM2SLC1A1
Aspartic Acid SCHEMBL28885521 1.00 GRIK1 (0.52) GRIK1GRIK2GRM1GRM2SLC1A1
Aspartic Acid SCHEMBL2459025 0.97 GRIK1 (0.54) GRIK1GRIK2GRM1GRM2SLC1A1
Aspartic Acid SCHEMBL4084810 0.97 GRIK1 (0.54) GRIK1GRIK2GRM1GRM2SLC1A1
Aspartic Acid SCHEMBL1085708 0.97 GRIK1 (0.54) GRIK1GRIK2GRM1GRM2SLC1A1
Aspartic Acid SCHEMBL11089943 0.97 GRIK1 (0.54) GRIK1GRIK2GRM1GRM2SLC1A1
Aspartic Acid SCHEMBL4084806 0.97 GRIK1 (0.54) GRIK1GRIK2GRM1GRM2SLC1A1
Aspartic Acid SCHEMBL2459027 0.97 GRIK1 (0.54) GRIK1GRIK2GRM1GRM2SLC1A1
Aspartic Acid SCHEMBL1085707 0.97 GRIK1 (0.54) GRIK1GRIK2GRM1GRM2SLC1A1
Aspartic Acid SCHEMBL15401937 0.97 GRIK1 (0.54) GRIK1GRIK2GRM1GRM2SLC1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 82 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2889369-B1 YEAST CULTURE MEDIUM UNIV YAMAGUCHI (JP) 2020-03-25 EP claimed
US-20250325591-A1 THERAPY FOR HEPATIC DISORDERS USING ADIPOSE-DERIVED MESENCHYMAL STEM CELL LINE UNIV KEIO (JP) 2025-10-23 US disclosed
US-20250146070-A1 METHOD FOR DETERMINING WHETHER ASC IS INCLUDED AT HIGH PURITY IN ADIPOSE TISSUE-DERIVED CELL POPULATION KEIO UNIVERSITY (JP) 2025-05-08 US disclosed
WO-2025033531-A1 TREATMENT OF TENDON DISORDERS USING PLATELETS PRODUCED FROM ADIPOSE TISSUE-DERIVED MESENCHYMAL STEM CELL LINE 慶應義塾 2025-02-13 WO disclosed
EP-4481053-A1 METHOD FOR DETERMINING WHETHER ASC IS INCLUDED AT HIGH PURITY IN ADIPOSE TISSUE-DERIVED CELL POPULATION Keio University (JP) 2024-12-25 EP disclosed
US-20240415893-A1 TREATMENT FOR KNEE OSTEOARTHRITIS USING ADIPOSE TISSUE-DERIVED MESENCHYMAL STEM CELL LINE KEIO UNIVERSITY (JP) 2024-12-19 US disclosed
WO-2024233705-A2 RECOMBINANT HOST CELL FOR PRODUCING ASPARTATE LYGOS, INC. (US) 2024-11-14 WO disclosed
EP-4450075-A1 THERAPY FOR HEPATIC DISORDERS USING ADIPOSE-DERIVED MESENCHYMAL STEM CELL LINE Keio University (JP) 2024-10-23 EP disclosed
EP-4431104-A1 TREATMENT FOR KNEE OSTEOARTHRITIS USING ADIPOSE TISSUE-DERIVED MESENCHYMAL STEM CELL LINE Keio University (JP) 2024-09-18 EP disclosed
CN-117946951-A Engineering vibrio thioalcaligenes for biosynthesis of ectoin and preparation method and application thereof 中国科学院微生物研究所 2024-04-30 CN disclosed
EP-0980404-A4 IMIDE-FREE AND MIXED AMIDE/IMIDE THERMAL SYNTHESIS OF POLYASPARTATE UNIV SOUTH ALABAMA (US) 2001-12-12 EP disclosed
EP-0980404-A1 IMIDE-FREE AND MIXED AMIDE/IMIDE THERMAL SYNTHESIS OF POLYASPARTATE UNIVERSITY OF SOUTH ALABAMA (US) 2000-02-23 EP disclosed
US-5981691-A THERMAL SYNTHESIS OF POLYASPARTATE WITHOUT FORMATION OF THE INTERMEDIATE POLYSUCCINIMIDE; HEATING SALT OF ASPARTIC ACID WITH POLYAMINE UNIVERSITY OF SOUTH ALABAMA (US) 1999-11-09 US disclosed
US-5908885-A IMPROVE THE WORKABILITY OF THE WET CEMENTITIOUS MIXTURE, REDUCE SLUMP LOSS DURING MIXING, TRANSPORT, AND PLACEMENT OF THE WET CEMENTIOUS MIXTURE; AND MAY PROVIDE EXTRA STRENGTH UPON HARDENING OF THE CEMENTITIOUS MATERIAL. UNIVERSITY OF SOUTH ALABAMA (US) 1999-06-01 US disclosed
WO-1998047964-A1 IMIDE-FREE AND MIXED AMIDE/IMIDE THERMAL SYNTHESIS OF POLYASPARTATE UNIVERSITY OF SOUTH ALABAMA (US) 1998-10-29 WO disclosed
US-5814321-A EMULSIFIER NONIONIC SURFACTANTS POLYHYDRIC ALCOHOLS WITH ESTERS, GLYCERIDES AND POLYOXYALKYLENE GLYCOL ESTERS AND ANTIGENS JURIDICAL FOUNDATION THE CHEMO-SERO-THERAPEUTIC RESEARCH INSTITUTE (JP) 1998-09-29 US disclosed
EP-0781559-A2 Oil adjuvant vaccine and method for preparing same Juridical Foundation, The Chemo-Sero-Therapeutic Research Institute (JP) 1997-07-02 EP disclosed
EP-0152275-B1 PRODUCTION OF AMINO ACIDS VIA BIOCONVERSION THE NUTRASWEET COMPANY (a Delaware corporation) (US) 1991-06-19 EP disclosed
US-4988515-A Antiischemic agents THE REGENTS OF THE UNIV. OF CALIF. (US) 1991-01-29 US disclosed
EP-0152275-A2 Production of amino acids via bioconversion THE NUTRASWEET COMPANY (a Delaware corporation) (US) 1985-08-21 EP disclosed