SCHEMBL40851

SCHEMBL40851

C=C(C)CCNc1nc(SC)nc2c1ncn2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O

nearest known ligand 0.66

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
PGK1 P00558 4/20 0.60
PGK2 P07205 4/20 0.60
KDM4E B2RXH2 1/20 0.56
PKM P14618 1/20 0.56
ADORA3 P0DMS8 4/20 0.55
ADORA1 P30542 4/20 0.55
ADORA2A P29274 2/20 0.54
SLC29A1 Q99808 1/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29389303 1.00 PGK1 (0.60) PGK1PGK2KDM4EPKMADORA3
SCHEMBL21685900 0.96 ADORA3 (0.61) PGK1PGK2KDM4EPKMADORA3
SCHEMBL20608780 0.95 SLC29A1 (0.63) ADORA3ADORA1ADORA2ASLC29A1
SCHEMBL29941603 0.93 PGK1 (0.52) PGK1PGK2KDM4EPKMADORA3
SCHEMBL28952609 0.88 KDM4E (0.59) PGK1PGK2KDM4EPKMADORA3
SCHEMBL546736 0.87 PGK1 (0.60) PGK1PGK2KDM4EPKMADORA3
SCHEMBL546737 0.87 PGK1 (0.60) PGK1PGK2KDM4EPKMADORA3
SCHEMBL1572888 0.87 PGK1 (0.47) PGK1PGK2KDM4EPKMADORA3
SCHEMBL18171845 0.86 KDM4E (0.57) PGK1PGK2KDM4EPKMADORA3
SCHEMBL18371513 0.86 KDM4E (0.57) PGK1PGK2KDM4EPKMADORA3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 4211 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4705468-A1 MAMMALIAN POLYCISTRONIC EXPRESSION SYSTEM FOR DIRECT TRANSLATION FROM RNA AND SECRETION OF CARGO California Institute of Technology (US) 2026-03-11 EP claimed
EP-4634380-A1 INTERNAL RIBOSOME ENTRY SITES FOR IMPROVED POLYNUCLEOTIDE TRANSLATION ModernaTX, Inc. (US) 2025-10-22 EP claimed
WO-2025137275-A1 NOVEL CAS NUCLEASES AND POLYNUCLEOTIDES ENCODING THE SAME MODERNATX, INC. (US) 2025-06-26 WO claimed
US-20250019719-A1 Purification and Purity Assessment of RNA Molecules Synthesized with Modified Nucleosides THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA 2025-01-16 US claimed
CN-117866948-B Negative selection method and system for purifying circular nucleic acid 上海环码生物医药有限公司 2024-12-13 CN claimed
WO-2024229296-A1 MAMMALIAN POLYCISTRONIC EXPRESSION SYSTEM FOR DIRECT TRANSLATION FROM RNA AND SECRETION OF CARGO CALIFORNIA INSTITUTE OF TECHNOLOGY (US) 2024-11-07 WO claimed
US-20240366793-A1 MAMMALIAN POLYCISTRONIC EXPRESSION SYSTEM FOR DIRECT TRANSLATION FROM RNA AND SECRETION OF CARGO CALIFORNIA INST OF TECHN (US) 2024-11-07 US claimed
US-20240279676-A1 CONSTRUCTS AND METHODS FOR PREPARING CIRCULAR RNAS AND USE THEREOF Shanghai Circode Biomed Co., Ltd. (CN) 2024-08-22 US claimed
US-20240229075-A1 IMPROVED NUCLEIC ACID SEQUENCE FOR CELL TYPE SPECIFIC EXPRESSION CureVac SE (DE) 2024-07-11 US claimed
WO-2024129779-A1 INTERNAL RIBOSOME ENTRY SITES FOR IMPROVED POLYNUCLEOTIDE TRANSLATION MODERNATX, INC. (US) 2024-06-20 WO claimed
US-20090214710-A1 Methods and Compositions For Increasing Fermentation of a Microorganism VDF FUTURECEUTICALS, INC. (US) 2009-08-27 US claimed
WO-2009036299-A2 COMPOSITIONS AND METHODS FOR THE IDENTIFICATION OF INHIBITORS OF RETROVIRAL INFECTION TRANA DISCOVERY (US) 2009-03-19 WO claimed
EP-1948822-A1 MULTICOMPONENT NUCLEIC ACID ENZYMES AND METHODS FOR THEIR USE JOHNSON & JOHNSON RESEARCH PTY LIMITED (AU) 2008-07-30 EP claimed
US-20070231810-A1 Multicomponent nucleic acid enzymes and methods for their use SPEEDX PTY LTD (AU) 2007-10-04 US claimed
WO-2007041774-A1 MULTICOMPONENT NUCLEIC ACID ENZYMES AND METHODS FOR THEIR USE JOHNSON & JOHNSON RESEARCH PTY LIMITED (AU) 2007-04-19 WO claimed
WO-2005020892-A2 PHARMACEUTICAL COMPOSITIONS AND METHODS FOR METABOLIC MODULATION MITOCHROMA RESEARCH, INC. (US) 2005-03-10 WO claimed
US-20050042327-A1 Methods and compositions for increasing fermentation of a microorganism VDF FUTURECEUTICALS 2005-02-24 US claimed
US-20030007961-A1 Orthomolecular vitamin E derivatives WILBURN MICHAEL D (US) 2003-01-09 US claimed
EP-0795029-A1 CHEMICAL LABELLING OF OBJECTS Pabio (NO) 1997-09-17 EP claimed
WO-1996017954-A1 CHEMICAL LABELLING OF OBJECTS PABIO (DK) 1996-06-13 WO claimed