Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HAVCR2 | Q8TDQ0 | 1/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.34 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.34 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.34 |
| ▸ | PAK4 | O96013 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | CSF1R | P07333 | 1/20 | 0.34 |
| ▸ | RET | P07949 | 1/20 | 0.34 |
| ▸ | IGF1R | P08069 | 1/20 | 0.34 |
| ▸ | MET | P08581 | 1/20 | 0.34 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.34 |
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
| ▸ | PIM1 | P11309 | 1/20 | 0.34 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.34 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.34 |
| ▸ | PRKACA | P17612 | 1/20 | 0.34 |
| ▸ | FLT1 | P17948 | 1/20 | 0.34 |
| ▸ | LTK | P29376 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2717720 | 0.73 | HAVCR2 (0.57) | HAVCR2AURKADAPK3JAK2PRKD3 | |
| SCHEMBL2829190 | 0.68 | HAVCR2 (0.55) | HAVCR2CDK5SMN1; SMN2NR1H2NR1H3 | |
| SCHEMBL2720744 | 0.67 | HAVCR2 (0.50) | HAVCR2NR1H2NR1H3POLBLMNA | |
| SCHEMBL2729630 | 0.66 | HAVCR2 (0.46) | HAVCR2AURKADAPK3JAK2PRKD3 | |
| SCHEMBL28623357 | 0.65 | HAVCR2 (0.51) | HAVCR2SMN1; SMN2MAPT | |
| SCHEMBL11867822 | 0.65 | HAVCR2 (0.70) | HAVCR2AURKADAPK3JAK2PRKD3 | |
| Hydrochloric Acid SCHEMBL11869520 | 0.64 | HAVCR2 (0.68) | HAVCR2AURKADAPK3JAK2PRKD3 | |
| SCHEMBL7494135 | 0.63 | HAVCR2 (0.72) | HAVCR2AURKADAPK3JAK2PRKD3 | |
| SCHEMBL11869509 | 0.62 | HAVCR2 (0.57) | HAVCR2AURKADAPK3JAK2PRKD3 | |
| SCHEMBL24298263 | 0.62 | HTR2C (0.33) | KDM4ECYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012061696-A1 | 5 -CYANO-4, 6 -DIAMINOPYRIMIDINE OR 6 -AMINOPURINE DERIVATIVES AS PI3K- DELTA INHIBITORS | AMGEN INC. (US) | 2012-05-10 | — | — | WO | disclosed |