SCHEMBL4085513

SCHEMBL4085513

O=c1ccn([C@]2(C(c3ccccc3)(c3ccccc3)c3ccccc3)O[C@H](CO)[C@@H](O)[C@H]2O)c(=O)[nH]1

nearest known ligand 0.43

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
SLC28A1 O00337 1/20 0.43
SLC28A2 O43868 1/20 0.43
SLC29A1 Q99808 1/20 0.43
SLC28A3 Q9HAS3 1/20 0.43
DUT P33316 15/20 0.39
P2RY14 Q15391 1/20 0.37
DDB1 Q16531 1/20 0.33
CRBN Q96SW2 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5671911 0.89 SLC28A1 (0.35) SLC28A1SLC28A2SLC29A1SLC28A3DUT
SCHEMBL1999188 0.86 SLC28A1 (0.48) SLC28A1SLC28A2SLC29A1SLC28A3P2RY14
SCHEMBL7524822 0.86 P2RY2 (0.36) DUTP2RY14
SCHEMBL29834207 0.83 SLC28A1 (0.35) SLC28A1SLC28A2SLC29A1SLC28A3DUT
SCHEMBL18049495 0.83 SLC28A1 (0.32) SLC28A1SLC28A2SLC29A1SLC28A3DUT
SCHEMBL7209223 0.82 SLC28A1 (0.32) SLC28A1SLC28A2SLC29A1SLC28A3DUT
Phosphoric Acid SCHEMBL21465157 0.82 SLC28A1 (0.44) SLC28A1SLC28A2SLC29A1SLC28A3P2RY14
SCHEMBL3827540 0.81 SLC28A1 (0.42) SLC28A1SLC28A2SLC29A1SLC28A3DUT
SCHEMBL7209224 0.80 SLC28A1 (0.33) SLC28A1SLC28A2SLC29A1SLC28A3DUT
SCHEMBL11430666 0.78 LMNA (0.45) SLC29A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5410033-A Deoxygenation of cis vicinal diols to make didehydro dideoxy nucleosidies and synthetic intermediates TEROCHEM LABORATORIES LIMITED (CA) 1995-04-25 US claimed
CN-109134570-A The preparation method of C4 '-fluoro Uridine phosphoramidite monomer and C4 '-fluoro uridine modification RNA 南开大学 2019-01-04 CN disclosed
US-7507859-B2 Functional synthetic molecules and macromolecules for gene delivery FIFTH BASE LLC (US) 2009-03-24 US disclosed
EP-1644479-A4 FUNCTIONAL SYNTHETIC MOLECULES AND MACROMOLECULES FOR GENE DELIVERY GRINSTAFF MARK W (US) 2008-04-23 EP disclosed
CN-101130540-A Nucleoside derivative containing selenium and its preparation method UNIV SHANGHAI JIAOTONG (CN) 2008-02-27 CN disclosed
US-20060241071-A1 Functional synthetic molecules and macromolecules for gene delivery FIFTH BASE LLC 2006-10-26 US disclosed
EP-1644479-A2 FUNCTIONAL SYNTHETIC MOLECULES AND MACROMOLECULES FOR GENE DELIVERY Grinstaff, Mark, W. (US) 2006-04-12 EP disclosed
WO-2005007810-A2 FUNCTIONAL SYNTHETIC MOLECULES AND MACROMOLECULES FOR GENE DELIVERY GRINSTAFF MARK W (US) 2005-01-27 WO disclosed
CN-1020106-C Process for pyrimidine derivatives HOFFMANN LA ROCHE (CH) 1993-03-17 CN disclosed
EP-0316017-A2 2',3'-Dideoxy-2'-fluoronucleosides Bristol-Myers Squibb Company (US) 1989-05-17 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060241071-A1 Functional synthetic molecules and macromolecules for gene delivery ANXA6, STING1, POLRMT SLC28A1 1592/4885SLC28A2 1890/4885SLC29A1 397/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.