Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 18/20 | 0.56 |
| ▸ | HTR2B | P41595 | 4/20 | 0.48 |
| ▸ | HTR1A | P08908 | 2/20 | 0.48 |
| ▸ | HTR7 | P34969 | 1/20 | 0.48 |
| ▸ | SCN4A | P35499 | 2/20 | 0.46 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.46 |
| ▸ | DRD2 | P14416 | 3/20 | 0.42 |
| ▸ | HTR2C | P28335 | 3/20 | 0.42 |
| ▸ | HTR1D | P28221 | 1/20 | 0.42 |
| ▸ | HTR1B | P28222 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3913015 | 0.93 | HTR6 (0.63) | HTR6HTR2BHTR1AHTR7SCN4A | |
| Hydrochloric Acid SCHEMBL4083731 | 0.93 | HTR6 (0.62) | HTR6HTR2BHTR1AHTR7SCN4A | |
| SCHEMBL3909209 | 0.89 | HTR6 (0.60) | HTR6HTR2BHTR1AHTR7DRD2 | |
| SCHEMBL3909249 | 0.77 | HTR6 (0.61) | HTR6HTR2BHTR1AHTR7DRD2 | |
| SCHEMBL4573351 | 0.73 | SCN4A (0.55) | HTR6SCN4ASCN9A | |
| SCHEMBL1775825 | 0.72 | HTR6 (0.63) | HTR6HTR2BHTR1AHTR7HTR1D | |
| SCHEMBL3916125 | 0.72 | HTR6 (1.00) | HTR6HTR2BHTR1AHTR7 | |
| Hydrochloric Acid SCHEMBL4075501 | 0.71 | HTR6 (0.98) | HTR6HTR2BHTR1AHTR7 | |
| Hydrochloric Acid SCHEMBL1773868 | 0.71 | HTR6 (0.62) | HTR6HTR2BHTR1AHTR7HTR1D | |
| SCHEMBL3918109 | 0.70 | HTR6 (1.00) | HTR6HTR2BHTR1AHTR7DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2024348-A2 | BENZOXAZOLE AND BENZOTHIAZOLE DERIVATIVES AS 5-HYDROXYTRYTAMINE-6 LIGANDS | Wyeth (US) | 2009-02-18 | — | — | EP | claimed |
| WO-2007142904-A2 | BENZOXAZOLE AND BENZOTHIAZOLE DERIVATIVES AS 5-HYDROXYTRYTAMINE-6 LIGANDS | WYETH (US) | 2007-12-13 | — | — | WO | claimed |