Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN4A | P35499 | 2/20 | 0.55 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.55 |
| ▸ | NPC1 | O15118 | 9/20 | 0.53 |
| ▸ | RAB9A | P51151 | 9/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | CTSL | P07711 | 1/20 | 0.47 |
| ▸ | CTSB | P07858 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CTSK | P43235 | 1/20 | 0.47 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.47 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.47 |
| ▸ | HTR6 | P50406 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3232592 | 0.80 | SCN4A (0.61) | SCN4ASCN9ANPC1RAB9ANPSR1 | |
| SCHEMBL3913015 | 0.79 | HTR6 (0.63) | SCN4ASCN9AHTR6 | |
| Hydrochloric Acid SCHEMBL4083731 | 0.78 | HTR6 (0.62) | SCN4ASCN9AHTR6 | |
| SCHEMBL2711602 | 0.77 | RAB9A (0.79) | SCN4ASCN9ANPC1RAB9ATSHR | |
| SCHEMBL2710695 | 0.77 | NPC1 (0.76) | SCN4ASCN9ANPC1RAB9AALDH1A1 | |
| SCHEMBL1981263 | 0.77 | RAB9A (0.76) | SCN4ASCN9ANPC1RAB9AAPOBEC3A | |
| SCHEMBL31349392 | 0.77 | NPC1 (0.70) | SCN4ASCN9ANPC1RAB9ACYP3A4 | |
| SCHEMBL13279558 | 0.77 | AR (0.70) | SCN4ASCN9ANPC1RAB9ACYP3A4 | |
| SCHEMBL2709859 | 0.77 | NPC1 (0.74) | SCN4ASCN9ANPC1RAB9ANPSR1 | |
| SCHEMBL3093424 | 0.77 | NPC1 (0.70) | SCN4ASCN9ANPC1RAB9ACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009001127-A1 | CYANOCYCLOPROPYLCARBOXAMIDES AS CATHEPSIN INHIBITORS | ASTRAZENECA AB (SE) | 2008-12-31 | — | — | WO | disclosed |
| WO-2009001127-A1 | CYANOCYCLOPROPYLCARBOXAMIDES AS CATHEPSIN INHIBITORS | ASTRAZENECA AB (SE) | 2008-12-31 | — | — | WO | disclosed |