Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | CASP1 | P29466 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 4/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | BCHE | P06276 | 1/20 | 0.43 |
| ▸ | PABPC1 | P11940 | 2/20 | 0.42 |
| ▸ | APOBEC3A | P31941 | 2/20 | 0.42 |
| ▸ | EIF4H | Q15056 | 2/20 | 0.42 |
| ▸ | APOBEC3G | Q9HC16 | 2/20 | 0.42 |
| ▸ | IDO1 | P14902 | 1/20 | 0.42 |
| ▸ | TDO2 | P48775 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1001101 | 1.00 | KDM4E (0.55) | KDM4EHSD17B10MAPK1CASP1MAPT | |
| SCHEMBL1001099 | 1.00 | KDM4E (0.55) | KDM4EHSD17B10MAPK1CASP1MAPT | |
| SCHEMBL4664068 | 0.82 | KDM4E (0.70) | KDM4EHSD17B10MAPK1CASP1MAPT | |
| SCHEMBL4664072 | 0.82 | KDM4E (0.70) | KDM4EHSD17B10MAPK1CASP1MAPT | |
| SCHEMBL4093743 | 0.74 | MAPT (0.64) | KDM4EHSD17B10MAPK1MAPTHPGD | |
| SCHEMBL249817 | 0.71 | ALDH1A1 (0.64) | KDM4EHSD17B10MAPK1CASP1MAPT | |
| SCHEMBL14524539 | 0.71 | ALDH1A1 (0.64) | KDM4EHSD17B10MAPK1CASP1MAPT | |
| SCHEMBL249816 | 0.71 | ALDH1A1 (0.64) | KDM4EHSD17B10MAPK1CASP1MAPT | |
| SCHEMBL1004133 | 0.70 | ALDH1A1 (0.57) | KDM4EHSD17B10MAPK1MAPTHPGD | |
| SCHEMBL1004132 | 0.70 | ALDH1A1 (0.57) | KDM4EHSD17B10MAPK1MAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8173360-B2 | Cell death inhibitor | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-05-08 | — | — | US | disclosed |
| US-8173360-B2 | Cell death inhibitor | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-05-08 | — | — | US | disclosed |
| EP-2270505-A1 | A method of screening a cell death inhibitor using macrophage migration inhibitory factor (MIF) | Takeda Pharmaceutical Company Limited (JP) | 2011-01-05 | — | — | EP | disclosed |
| US-20100099106-A1 | CELL DEATH INHIBITOR | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-04-22 | — | — | US | disclosed |
| US-20100099106-A1 | CELL DEATH INHIBITOR | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-04-22 | — | — | US | disclosed |