Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.64 |
| ▸ | POLB | P06746 | 4/20 | 0.64 |
| ▸ | HPGD | P15428 | 3/20 | 0.64 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.64 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.46 |
| ▸ | GSK3B | P49841 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | CASP3 | P42574 | 1/20 | 0.38 |
| ▸ | CASP2 | P42575 | 1/20 | 0.38 |
| ▸ | CASP7 | P55210 | 1/20 | 0.38 |
| ▸ | CASP6 | P55212 | 1/20 | 0.38 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 6/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4086624 | 0.74 | KDM4E (0.55) | MAPTPOLBHPGDTDP1L3MBTL1 | |
| SCHEMBL1001099 | 0.74 | KDM4E (0.55) | MAPTPOLBHPGDTDP1L3MBTL1 | |
| SCHEMBL1001101 | 0.74 | KDM4E (0.55) | MAPTPOLBHPGDTDP1L3MBTL1 | |
| SCHEMBL11319550 | 0.73 | NOX1 (0.58) | MAPTPOLBHPGDTDP1L3MBTL1 | |
| SCHEMBL3194688 | 0.73 | L3MBTL1 (0.58) | MAPTPOLBHPGDTDP1L3MBTL1 | |
| SCHEMBL8988 | 0.72 | L3MBTL1 (1.00) | MAPTPOLBHPGDTDP1L3MBTL1 | |
| SCHEMBL24413829 | 0.68 | MAPT (0.66) | MAPTPOLBL3MBTL1ALDH1A1HSD17B10 | |
| Phthalimide SCHEMBL28635005 | 0.68 | GSK3B (0.75) | MAPTPOLBHPGDTDP1L3MBTL1 | |
| Phthalimide SCHEMBL335240 | 0.68 | GSK3B (0.75) | MAPTPOLBHPGDTDP1L3MBTL1 | |
| SCHEMBL15905962 | 0.67 | LMNA (0.60) | MAPTHPGDL3MBTL1ALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8173360-B2 | Cell death inhibitor | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-05-08 | — | — | US | disclosed |
| US-20100099106-A1 | CELL DEATH INHIBITOR | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-04-22 | — | — | US | disclosed |