Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RHEB | Q15382 | 1/20 | 0.52 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.49 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.49 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 5/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | NQO2 | P16083 | 1/20 | 0.41 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4898966 | 0.93 | ALOX5 (0.59) | RHEBALOX5CYP1A2CYP1A1CYP19A1 | |
| SCHEMBL29418792 | 0.93 | ALOX5 (0.59) | RHEBALOX5CYP1A2CYP1A1CYP19A1 | |
| SCHEMBL29005956 | 0.81 | MAOB (0.50) | RHEBALOX5MAOB | |
| SCHEMBL30049245 | 0.79 | NQO2 (0.61) | ALOX5CYP1A2CYP2C19HIF1AMEN1 | |
| SCHEMBL30643782 | 0.79 | NQO2 (0.61) | ALOX5CYP1A2CYP2C19HIF1AMEN1 | |
| SCHEMBL1055937 | 0.79 | NQO2 (0.61) | ALOX5CYP1A2CYP2C19HIF1AMEN1 | |
| SCHEMBL5255141 | 0.77 | ALOX5 (0.50) | RHEBALOX5CYP1A2CYP1A1CYP19A1 | |
| SCHEMBL4083845 | 0.76 | PRMT5 (0.48) | RHEBALOX5LMNAMAOBMEN1 | |
| SCHEMBL2424374 | 0.76 | RHEB (0.48) | RHEBALOX5MAOBMEN1KMT2A | |
| SCHEMBL21822345 | 0.76 | ALOX5 (0.57) | RHEBALOX5CYP1A2CYP1A1CYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7534808-B2 | Indolylmaleimide derivatives | ELANCO TIERGESUNDHEIT AG (CH) | 2009-05-19 | — | — | US | disclosed |
| US-7235555-B2 | Indolylmaleimide derivatives | NOVARTIS AG (CH) | 2007-06-26 | — | — | US | disclosed |
| US-20050119274-A1 | Indolylmaleimide derivatives | NOVARTIS AG (CH) | 2005-06-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050119274-A1 | Indolylmaleimide derivatives | MYLK2, DGKK, LCK | RHEB 1021/4885ALOX5 2541/4885CYP1A2 4143/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.