Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 1/20 | 0.50 |
| ▸ | MAOB | P27338 | 5/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | RHEB | Q15382 | 1/20 | 0.45 |
| ▸ | MAOA | P21397 | 2/20 | 0.45 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 2/20 | 0.42 |
| ▸ | CA1 | P00915 | 2/20 | 0.42 |
| ▸ | CA2 | P00918 | 2/20 | 0.42 |
| ▸ | CA4 | P22748 | 2/20 | 0.42 |
| ▸ | CA7 | P43166 | 2/20 | 0.42 |
| ▸ | CA9 | Q16790 | 2/20 | 0.42 |
| ▸ | CA5A | P35218 | 1/20 | 0.42 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4898966 | 0.83 | ALOX5 (0.59) | ALOX5MAOBNPC1RAB9ARHEB | |
| SCHEMBL29418792 | 0.83 | ALOX5 (0.59) | ALOX5MAOBNPC1RAB9ARHEB | |
| SCHEMBL1562291 | 0.78 | MAOB (0.60) | ALOX5MAOBNPC1RAB9AMAOA | |
| SCHEMBL4992573 | 0.78 | MEN1 (0.47) | ALOX5MAOBNPC1RAB9AMAOA | |
| SCHEMBL12754483 | 0.77 | MAOB (0.59) | ALOX5MAOBRAB9ARHEBMAOA | |
| SCHEMBL4087244 | 0.77 | RHEB (0.52) | ALOX5MAOBRHEBMRGPRX4MEN1 | |
| SCHEMBL24750130 | 0.75 | MAOB (0.53) | MAOBMAOAMRGPRX4 | |
| SCHEMBL28514685 | 0.75 | CFD (0.50) | PIN1 | |
| SCHEMBL31009359 | 0.75 | MAOB (0.53) | MAOBMAOAMRGPRX4 | |
| SCHEMBL5988383 | 0.75 | MRGPRX4 (0.69) | ALOX5MAOBNPC1RAB9AMAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1487822-B1 | PYRROLE-2,5-DIONE DERIVATIVES AND THEIR USE AS GSK-3 INHIBITORS | LILLY CO ELI (US) | 2007-08-01 | — | — | EP | disclosed |
| CN-1639152-A | Pyrrole-2, 5-dione derivatives and their use as GSK-3 inhibitors | LILLY CO ELI (US) | 2005-07-13 | — | — | CN | disclosed |