Trovafloxacin

Trovafloxacin

SCHEMBL40875

CS(=O)(=O)O.NC1[C@H]2CN(c3nc4c(cc3F)c(=O)c(C(=O)O)cn4-c3ccc(F)cc3F)C[C@@H]12

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

gyrAgyrBparCparE

The experimentally established mechanism targets of Trovafloxacin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 5/20 1.00
KDM4E B2RXH2 5/20 1.00
ALDH1A1 P00352 4/20 1.00
HSD17B10 Q99714 3/20 1.00
HPGD P15428 3/20 1.00
POLB P06746 2/20 1.00
XBP1 P17861 1/20 1.00
NFKB1 P19838 1/20 1.00
HTT P42858 1/20 1.00
NFKB2 Q00653 1/20 1.00
RELA Q04206 1/20 1.00
EPHA2 P29317 1/20 0.90
FLT4 P35916 1/20 0.90
GSK3B P49841 1/20 0.90
RARB P10826 1/20 0.90
TBXAS1 P24557 1/20 0.90
SLC6A3 Q01959 1/20 0.90
KMT2A Q03164 3/20 0.70
DPP4 P27487 6/20 0.51
ABCC4 O15439 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Trovafloxacin SCHEMBL8963965 1.00 LMNA (1.00) LMNAKDM4EALDH1A1HSD17B10HPGD
Trovafloxacin SCHEMBL29711203 1.00 LMNA (1.00) LMNAKDM4EALDH1A1HSD17B10HPGD
Trovafloxacin SCHEMBL29711214 1.00 LMNA (1.00) LMNAKDM4EALDH1A1HSD17B10HPGD
Trovafloxacin SCHEMBL2222007 1.00 LMNA (1.00) LMNAKDM4EALDH1A1HSD17B10HPGD
Trovafloxacin SCHEMBL40874 1.00 LMNA (1.00) LMNAKDM4EALDH1A1HSD17B10HPGD
Trovafloxacin SCHEMBL1229498 0.99 LMNA (0.98) LMNAKDM4EALDH1A1HSD17B10HPGD
Trovafloxacin SCHEMBL1229500 0.99 LMNA (0.98) LMNAKDM4EALDH1A1HSD17B10HPGD
Trovafloxacin SCHEMBL8561863 0.99 LMNA (0.98) LMNAKDM4EALDH1A1HSD17B10HPGD
Trovafloxacin SCHEMBL9177464 0.95 EPHA2 (1.00) LMNAKDM4EALDH1A1HSD17B10HPGD
Trovafloxacin SCHEMBL34466 0.95 EPHA2 (1.00) LMNAKDM4EALDH1A1HSD17B10HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 884 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4724049-A1 MODIFIED RELEASE FILL COMPOSITIONS FOR DOSAGE FORMS AND METHODS OF PREPARATION AND USE THEREOF Catalent Ontario Limited (CA) 2026-04-15 EP claimed
EP-3452124-B1 HEMOSTATIC DEVICES AND METHODS OF USE MEDTRONIC INC (US) 2025-10-08 EP claimed
EP-3452123-B1 HEMOSTATIC DEVICES AND METHODS OF USE MEDTRONIC INC (US) 2025-09-24 EP claimed
EP-3230500-B1 METHODS OF ORIENTING MULTIFILAMENT YARN AND MONOFILAMENTS OF POLY-4-HYDROXYBUTYRATE AND COPOLYMERS THEREOF TEPHA INC (US) 2025-06-18 EP claimed
WO-2024254056-A1 MODIFIED RELEASE FILL COMPOSITIONS FOR DOSAGE FORMS AND METHODS OF PREPARATION AND USE THEREOF CATALENT ONTARIO LIMITED (CA) 2024-12-12 WO claimed
EP-3678715-B1 CALENDERED SURGICAL MESHES COMPRISING POLYHYDROXYALKANOATES TEPHA INC (US) 2024-10-30 EP claimed
EP-4442767-A2 METHODS FOR 3D PRINTING OF POLY-4-HYDROXYBUTYRATE Tepha, Inc. (US) 2024-10-09 EP claimed
EP-3802062-B1 METHODS FOR 3D PRINTING OF POLY-4-HYDROXYBUTYRATE TEPHA INC (US) 2024-09-18 EP claimed
CN-117858696-A Antibiotic pharmaceutical composition capable of subcutaneous administration 上海宝济药业股份有限公司 2024-04-09 CN claimed
EP-3452122-B1 HEMOSTATIC DEVICES AND METHODS OF USE MEDTRONIC INC (US) 2023-03-22 EP claimed
US-20040253314-A1 Melt extrusion of salts of active ingredients ROEHM GMBH (DE) 2004-12-16 US claimed
EP-1357928-A2 A NOVEL PHARMACEUTICAL COMPOUND AND METHODS OF MAKING AND USING SAME New River Pharmaceuticals Inc. (US) 2003-11-05 EP claimed
EP-1057828-B1 Trovafloxacin oral suspensions PFIZER PROD INC (US) 2003-03-19 EP claimed
WO-2003020200-A2 A NOVEL PHARMACEUTICAL COMPOUND AND METHODS OF MAKING AND USING SAME NEW RIVER PHARMACEUTICALS INC. (US) 2003-03-13 WO claimed
US-6514492-B1 Taste masking of oral quinolone liquid preparations using ion exchange resins SCHERING-PLOUGH VETERINARY CORPORATION 2003-02-04 US claimed
US-6239141-B1 ANTIBIOTIC PFIZER INC. 2001-05-29 US claimed
US-6187341-B1 ACTIVE MATERIAL WITH LUBRICANTS PFIZER INC. 2001-02-13 US claimed
EP-1057828-A2 Trovafloxacin oral suspensions Pfizer Products Inc. (US) 2000-12-06 EP claimed
CN-1227743-A Trovafloxacin mesylate tablet PFIZER PROD INC (US) 1999-09-08 CN claimed
EP-0930068-A2 Trovafloxacin mesylate tablet Pfizer Products Inc. (US) 1999-07-21 EP claimed