Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Trovafloxacin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.98 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.98 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.98 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.98 |
| ▸ | HPGD | P15428 | 3/20 | 0.98 |
| ▸ | POLB | P06746 | 2/20 | 0.98 |
| ▸ | XBP1 | P17861 | 1/20 | 0.98 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.98 |
| ▸ | HTT | P42858 | 1/20 | 0.98 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.98 |
| ▸ | RELA | Q04206 | 1/20 | 0.98 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.88 |
| ▸ | FLT4 | P35916 | 1/20 | 0.88 |
| ▸ | GSK3B | P49841 | 1/20 | 0.88 |
| ▸ | RARB | P10826 | 1/20 | 0.88 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.88 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.88 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.69 |
| ▸ | DPP4 | P27487 | 6/20 | 0.50 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trovafloxacin SCHEMBL29711203 | 0.99 | LMNA (1.00) | LMNAKDM4EALDH1A1HSD17B10HPGD | |
| Trovafloxacin SCHEMBL40875 | 0.99 | LMNA (1.00) | LMNAKDM4EALDH1A1HSD17B10HPGD | |
| Trovafloxacin SCHEMBL8963965 | 0.99 | LMNA (1.00) | LMNAKDM4EALDH1A1HSD17B10HPGD | |
| Trovafloxacin SCHEMBL2222007 | 0.99 | LMNA (1.00) | LMNAKDM4EALDH1A1HSD17B10HPGD | |
| Trovafloxacin SCHEMBL40874 | 0.99 | LMNA (1.00) | LMNAKDM4EALDH1A1HSD17B10HPGD | |
| Trovafloxacin SCHEMBL29711214 | 0.99 | LMNA (1.00) | LMNAKDM4EALDH1A1HSD17B10HPGD | |
| Trovafloxacin SCHEMBL1229500 | 0.98 | LMNA (0.98) | LMNAKDM4EALDH1A1HSD17B10HPGD | |
| Trovafloxacin SCHEMBL1229498 | 0.98 | LMNA (0.98) | LMNAKDM4EALDH1A1HSD17B10HPGD | |
| Trovafloxacin SCHEMBL1229029 | 0.95 | EPHA2 (0.98) | LMNAKDM4EALDH1A1HSD17B10HPGD | |
| Trovafloxacin SCHEMBL1229033 | 0.95 | EPHA2 (0.98) | LMNAKDM4EALDH1A1HSD17B10HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0850060-A1 | ZWITTERIONIC FORMS OF TROVAFLOXACIN | PFIZER INC. (US) | 1998-07-01 | — | — | EP | disclosed |
| WO-1997007800-A1 | ZWITTERIONIC FORMS OF TROVAFLOXACIN | PFIZER INC. (US) | 1997-03-06 | — | — | WO | disclosed |