Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 1/20 | 0.42 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.41 |
| ▸ | KAT6A | Q92794 | 2/20 | 0.41 |
| ▸ | MAOB | P27338 | 3/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.38 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.38 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.38 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.38 |
| ▸ | MGLL | Q99685 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4088046 | 1.00 | ESR1 (0.42) | ESR1TRPV1KAT6AMAOBHDAC8 | |
| SCHEMBL4088036 | 1.00 | ESR1 (0.42) | ESR1TRPV1KAT6AMAOBHDAC8 | |
| SCHEMBL3942285 | 0.88 | CYP1A1 (0.48) | MAOBCYP1A1CYP1B1KDRNPC1 | |
| SCHEMBL3942282 | 0.88 | CYP1A1 (0.48) | MAOBCYP1A1CYP1B1KDRNPC1 | |
| SCHEMBL3942276 | 0.88 | CYP1A1 (0.48) | MAOBCYP1A1CYP1B1KDRNPC1 | |
| SCHEMBL3944397 | 0.88 | TRPV1 (0.53) | TRPV1MAOBNR4A2CYP1A1CYP1B1 | |
| SCHEMBL3944403 | 0.88 | TRPV1 (0.53) | TRPV1MAOBNR4A2CYP1A1CYP1B1 | |
| SCHEMBL3944401 | 0.88 | TRPV1 (0.53) | TRPV1MAOBNR4A2CYP1A1CYP1B1 | |
| SCHEMBL3939647 | 0.86 | MEN1 (0.44) | KAT6AMAOBMRGPRX4NR4A2CYP1A1 | |
| SCHEMBL3939639 | 0.86 | MEN1 (0.44) | KAT6AMAOBMRGPRX4NR4A2CYP1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090203667-A1 | PENTADIENAMIDE DERIVATIVES | KYOWA HAKKO KIRIN CO., LTD. (JP) | 2009-08-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090203667-A1 | PENTADIENAMIDE DERIVATIVES | PRMT1, REN, NGLY1 | ESR1 2873/4885TRPV1 2741/4885KAT6A 1471/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.