Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP28 | Q96RU2 | 6/20 | 0.44 |
| ▸ | ALB | P02768 | 1/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.44 |
| ▸ | PDE4A | P27815 | 1/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.44 |
| ▸ | DRD3 | P35462 | 1/20 | 0.44 |
| ▸ | HTR2B | P41595 | 1/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.44 |
| ▸ | SHH | Q15465 | 1/20 | 0.44 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.44 |
| ▸ | SMO | Q99835 | 1/20 | 0.44 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.44 |
| ▸ | APLNR | P35414 | 1/20 | 0.41 |
| ▸ | BACE1 | P56817 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27756785 | 0.89 | USP28 (0.44) | USP28ALBHTR1ASLC6A2PDE4A | |
| SCHEMBL1625019 | 0.85 | USP28 (0.64) | USP28ALBHTR1ASLC6A2PDE4A | |
| SCHEMBL1624792 | 0.85 | USP28 (0.49) | USP28ALBHTR1ASLC6A2PDE4A | |
| SCHEMBL1625829 | 0.83 | USP28 (0.52) | USP28ALBHTR1ASLC6A2PDE4A | |
| SCHEMBL1625226 | 0.83 | MEN1 (0.48) | USP28ALBHTR1ASLC6A2PDE4A | |
| SCHEMBL1625028 | 0.83 | USP28 (0.44) | USP28ALBHTR1ASLC6A2PDE4A | |
| SCHEMBL1624570 | 0.82 | USP28 (0.51) | USP28ALBHTR1ASLC6A2PDE4A | |
| SCHEMBL1624999 | 0.82 | TAS1R3 (0.48) | USP28ALBHTR1ASLC6A2PDE4A | |
| SCHEMBL1622677 | 0.82 | NR2E3 (0.51) | — | |
| SCHEMBL27756796 | 0.81 | MAPT (0.52) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2044065-A2 | COMPOUNDS AND COMPOSITIONS AS HEDGEHOG PATHWAY MODULATORS | IRM, LLC (BM) | 2009-04-08 | — | — | EP | claimed |
| WO-2008014291-A2 | COMPOUNDS AND COMPOSITIONS AS HEDGEHOG SIGNALING PATHWAY MODULATORS | IRM LLC (BM) | 2008-01-31 | — | — | WO | claimed |