SCHEMBL40884

SCHEMBL40884

[CH2]Oc1ccc(OC)cc1

nearest known ligand 0.69

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA1 P00915 3/20 0.69
CA2 P00918 3/20 0.69
CA7 P43166 2/20 0.69
CA9 Q16790 2/20 0.69
CA12 O43570 1/20 0.69
CA14 Q9ULX7 1/20 0.69
ACHE P22303 1/20 0.55
TDP1 Q9NUW8 3/20 0.52
MAPK1 P28482 2/20 0.52
ALDH1A1 P00352 4/20 0.50
CYP3A4 P08684 2/20 0.50
KDM4E B2RXH2 1/20 0.50
NPC1 O15118 1/20 0.50
GAA P10253 1/20 0.50
MAPT P10636 1/20 0.50
THRB P10828 1/20 0.50
RECQL P46063 1/20 0.50
RAB9A P51151 1/20 0.50
NPSR1 Q6W5P4 1/20 0.50
L3MBTL1 Q9Y468 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2091379 0.92 ESR2 (0.58) CA1CA2CA7CA9CA12
1,4-Dimethoxybenzene SCHEMBL21802643 0.83 CA1 (1.00) CA1CA2CA7CA9CA12
1,4-Dimethoxybenzene SCHEMBL8489 0.83 CA1 (1.00) CA1CA2CA7CA9CA12
1,4-Dimethoxybenzene SCHEMBL4957328 0.78 CA1 (0.73) CA1CA2CA7CA9CA12
1,4-Dimethoxybenzene SCHEMBL11373286 0.76 CA1 (0.85) CA1CA2CA7CA9CA12
SCHEMBL3223 0.75
SCHEMBL1047182 0.75 ALDH1A1 (0.69) CA1CA2CA7CA9CA12
SCHEMBL10761 0.75
SCHEMBL83811 0.73 CA1 (0.79) CA1CA2CA7CA9CA12
SCHEMBL7534896 0.73 CA1 (0.79) CA1CA2CA7CA9CA12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 4888 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2991655-B1 COMPOSITIONS AND METHODS FOR ALTERING SECOND MESSENGER SIGNALING MEMORIAL SLOAN KETTERING CANCER CENTER (US) 2024-04-10 EP claimed
EP-3606528-B1 TRICYCLIC COMPOUNDS AS GLYCOGEN SYNTHASE KINASE 3 (GSK3) INHIBITORS AND USES THEREOF BROAD INST INC (US) 2023-10-18 EP claimed
WO-2023061415-A1 THIADIAZOLYL DERIVATIVES, COMPOSITIONS AND USES THEREOF DANATLAS PHARMACEUTICALS CO., LTD. (CN) 2023-04-20 WO claimed
EP-3649135-B1 SYNTHESIS OF HALICHONDRINS HARVARD COLLEGE (US) 2022-12-28 EP claimed
US-11241435-B2 Uses of salt-inducible kinase (SIK) inhibitors for treating osteoporosis THE GENERAL HOSPITAL CORPORATION (US) 2022-02-08 US claimed
EP-3172213-B1 MACROCYCLIC KINASE INHIBITORS AND USES THEREOF DANA FARBER CANCER INST INC (US) 2021-09-22 EP claimed
EP-3092220-B1 VITAMIN C PRODRUGS AND USES THEREOF UNIV FLORIDA (US) 2021-01-20 EP claimed
US-10870651-B2 Inhibitors of cyclin-dependent kinase 7 (CDK7) DANA-FARBER CANCER INSTITUTE, INC. (US) 2020-12-22 US claimed
EP-3171874-B1 IMIDAZOLYL KINASE INHIBITORS AND USES THEREOF DANA FARBER CANCER INST INC (US) 2020-11-18 EP claimed
EP-2016044-B1 PENTACYCLINE DERIVATIVES FOR THE TREATMENT OF INFECTIONS HARVARD COLLEGE (US) 2020-06-10 EP claimed
US-4689411-A ANTIBIOTICS OTSUKA KAGAKU YAKUHIN KABUSHIKI KAISHA (JP) 1987-08-25 US claimed
US-4665166-A FROM THIAZOLIDINEACETIDINONE COMPOUND OTSUKA KAGAKU KABUSHIKI KAISHA (JP) 1987-05-12 US claimed
US-4566996-A Process for preparing azetidinone derivatives Otsuke Kagaku Yakuhin Kabushiki Kaisha (JP) 1986-01-28 US claimed
US-4499265-A CYCLIATION OF 2(>-OXO-4-THIA-2,6-DIAZABICYCLO(3.2.0)HEPT-2-EN-6-VL)-3-IODOMETHYL-3 -BUTENOIC ACID OTSUKA KAGAKU YAKUHIN KABUSHIKI KAISHA (JP) 1985-02-12 US claimed
US-4426377-A BACTERICIDES BEECHAM GROUP LIMITED (GB) 1984-01-17 US claimed
US-4181733-A ANTIBIOTICS MERCK & CO., INC. (US) 1980-01-01 US claimed
US-4167630-A Process for epimerizing beta-lactam antibiotic compounds, and related products MERCK & CO., INC. (US) 1979-09-11 US claimed
US-4156725-A MICROBIOCIDES BURROUGHS WELLCOME CO. (US) 1979-05-29 US claimed
US-4051132-A Process for epimerizing beta-lactam antibiotic compounds by means of an acid quench MERCK & CO., INC. (US) 1977-09-27 US claimed
US-3962224-A CHEMICAL INTERMEDIATES FOR ANTIBIOTICS MERCK & CO., INC. (US) 1976-06-08 US claimed