Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
| ▸ | PTP4A1 | Q93096 | 1/20 | 0.30 |
| ▸ | MIF | P14174 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3660855 | 0.82 | CYP2C9 (0.44) | ALDH1A1TSHRCYP2C9HCAR2L3MBTL1 | |
| SCHEMBL3660857 | 0.82 | CYP2C9 (0.44) | ALDH1A1TSHRCYP2C9HCAR2L3MBTL1 | |
| SCHEMBL12894799 | 0.72 | CYP2C9 (0.47) | ALDH1A1TSHRCYP2C9L3MBTL1KDM4E | |
| SCHEMBL601377 | 0.72 | ALDH1A1 (0.44) | ALDH1A1TSHRCYP2C9HCAR2L3MBTL1 | |
| SCHEMBL4525123 | 0.72 | ALDH1A1 (0.44) | ALDH1A1TSHRCYP2C9HCAR2L3MBTL1 | |
| SCHEMBL601376 | 0.72 | ALDH1A1 (0.44) | ALDH1A1TSHRCYP2C9HCAR2L3MBTL1 | |
| SCHEMBL508464 | 0.71 | ALDH1A1 (0.42) | ALDH1A1TSHRCYP2C9HCAR2L3MBTL1 | |
| SCHEMBL188482 | 0.71 | ALDH1A1 (0.42) | ALDH1A1TSHRCYP2C9HCAR2L3MBTL1 | |
| SCHEMBL4642638 | 0.71 | ALDH1A1 (0.42) | ALDH1A1TSHRCYP2C9HCAR2L3MBTL1 | |
| SCHEMBL25883401 | 0.70 | ALDH1A1 (0.40) | ALDH1A1TSHRCYP2C9L3MBTL1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090215778-A1 | Alpha-substituted Arylmethyl Piperazine Pyrazolo [1,5-alpha]Pyrimidine Amide Derivatives | PANACOS PHARMACEUTICALS, INC. (US) | 2009-08-27 | — | — | US | disclosed |
| WO-2008134036-A1 | ALPHA-SUBSTITUTED ARYLMETHYL PIPERAZINE PYRAZOLO[1,5-α]PYRIMIDINE AMIDE DERIVATIVES | PANACOS PHARMACEUTICALS, INC. (US) | 2008-11-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090215778-A1 | Alpha-substituted Arylmethyl Piperazine Pyrazolo [1,5-alpha]Pyrimidine Amide Derivatives | THPO, DPYD, TPMT | ALDH1A1 116/4885TSHR 4375/4885CYP2C9 590/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.