⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL471123 | 0.83 | LMNA (0.30) | — | |
| SCHEMBL23170573 | 0.77 | — | — | |
| SCHEMBL16791185 | 0.77 | ALDH1A1 (0.31) | — | |
| SCHEMBL18557544 | 0.77 | — | — | |
| SCHEMBL13206000 | 0.73 | — | — | |
| Metformin SCHEMBL1766280 | 0.73 | LMNA (0.36) | — | |
| Metformin SCHEMBL8944 | 0.73 | — | — | |
| SCHEMBL12563236 | 0.73 | — | — | |
| SCHEMBL16791181 | 0.73 | ALDH1A1 (0.30) | — | |
| SCHEMBL3055662 | 0.71 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 37 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180214396-A1 | COMPOSITION FOR TREATING DIABETES MELLITUS | KATO YASUMASA (JP) | 2018-08-02 | — | — | US | disclosed |
| US-20180214396-A1 | COMPOSITION FOR TREATING DIABETES MELLITUS | KATO YASUMASA (JP) | 2018-08-02 | — | — | US | disclosed |
| US-9862693-B2 | Compounds and methods of treating cancer | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2018-01-09 | — | — | US | disclosed |
| US-20170327455-A1 | Omefibrates for Treating Dyslipidemia and Cardiovascular Disease | JIVA PHARMA, INC. (US) | 2017-11-16 | — | — | US | disclosed |
| US-20170196890-A1 | TGR5 AGONIST COMPLEXES FOR TREATING DIABETES AND CANCER | CITY OF HOPE | 2017-07-13 | — | — | US | disclosed |
| US-20170157069-A1 | COMPOSITION USING METFORMIN FOR PREVENTING OR TREATING IMMUNE DISEASES INCLUDING LUPUS | Catholic University Industry Academic Cooperation Foundation (KR) | 2017-06-08 | — | — | US | disclosed |
| US-9371276-B1 | Compositions and methods for the treatment of hyperglycemia and metabolic syndrome | ALAPATI MOHAN MURALI (IN) | 2016-06-21 | — | — | US | disclosed |
| US-20160101071-A1 | COMBINATION CANCER TREATMENT | WISCONSIN ALUMNI RESEARCH FOUNDATION | 2016-04-14 | — | — | US | disclosed |
| US-20150344402-A1 | Omefibrates for Treating Dyslipidemia and Cardiovascular Disease | JIVA PHARMA, INC. (US) | 2015-12-03 | — | — | US | disclosed |
| US-9174931-B2 | Compositions for the treatment of diabetes and pre-diabetes | CELLIX BIO PRIVATE LIMITED (IN) | 2015-11-03 | — | — | US | disclosed |
| US-20140018371-A1 | Modulators Of The GPR119 Receptor And The Treatment Of Disorders Related Thereto | ARENA PHARMACEUTICALS, INC. (US) | 2014-01-16 | — | — | US | disclosed |
| US-8581001-B2 | Metformin-cysteine prodrug | CODMAN & SHURTLEFF (US) | 2013-11-12 | — | — | US | disclosed |
| US-8461331-B2 | Method for the production of 3,6-dihydro-L, 3, 5-triazine derivatives from metformin and paraldehyde derivatives | POXEL SAS (FR) | 2013-06-11 | — | — | US | disclosed |
| US-20130023494-A1 | MODULATORS OF THE GPR119 RECEPTOR AND THE TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARMACEUTICALS, INC. (US) | 2013-01-24 | — | — | US | disclosed |
| US-20120135952-A1 | BUTYRIC ACID SALT OF N,N-DIMETHYL IMIDOCARBON IMIDIC DIAMIDE, METHOD OF PREPARING SAME, AND PHARMACEUTICAL COMPOSITIONS AND COMBINATIONS CONTAINING SAME | HANALL BIOPHARMA CO., LTD. (KR) | 2012-05-31 | — | — | US | disclosed |
| US-20120065176-A1 | TREATMENT OF MUSCLE DISEASE CHARACTERIZED BY INSULIN RESISTANCE | THE UNIVERSITY OF OTTAWA (CA) | 2012-03-15 | — | — | US | disclosed |
| US-20120016121-A1 | Process for the separation of enantiomers of 3,6-dihydro-1,3,5-triazine derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2012-01-19 | — | — | US | disclosed |
| US-20110257432-A1 | Metformin-Cysteine Prodrug | CODMAN & SHURTLEFF | 2011-10-20 | — | — | US | disclosed |
| US-20110118463-A1 | METHOD FOR THE PRODUCTION OF 3,6-DIHYDRO-L, 3, 5-TRIAZINE DERIVATIVES FROM METFORMIN AND PARALDEHYDE DERIVATIVES | POXEL SAS | 2011-05-19 | — | — | US | disclosed |
| US-7169407-B1 | Carbonyl stress-decreasing agent | Miyata, Toshio (JP) | 2007-01-30 | — | — | US | disclosed |