SCHEMBL4089639

SCHEMBL4089639

Cc1cc(C(=O)CCc2cc(-c3ccc(C(F)(F)F)cc3)nn2Cc2ccccc2)ccc1OC(C)(C)C(=O)O

nearest known ligand 0.49

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
PPARD Q03181 18/20 0.49
PPARA Q07869 18/20 0.49
PPARG P37231 14/20 0.49
HDAC3 O15379 2/20 0.42
HDAC4 P56524 2/20 0.42
HDAC1 Q13547 2/20 0.42
HDAC7 Q8WUI4 2/20 0.42
HDAC2 Q92769 2/20 0.42
HDAC10 Q969S8 2/20 0.42
HDAC11 Q96DB2 2/20 0.42
HDAC8 Q9BY41 2/20 0.42
HDAC6 Q9UBN7 2/20 0.42
HDAC9 Q9UKV0 2/20 0.42
HDAC5 Q9UQL6 2/20 0.42
NCOR2 Q9Y618 2/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4090763 0.92 PPARD (0.42) PPARDPPARAPPARGHDAC3HDAC4
SCHEMBL4095560 0.88 PPARD (0.51) PPARDPPARAPPARG
SCHEMBL4095633 0.87 PPARD (0.45) PPARDPPARAPPARG
SCHEMBL4095867 0.86 PPARA (0.46) PPARDPPARAPPARG
SCHEMBL4271873 0.86 HDAC1 (0.47) HDAC3HDAC4HDAC1HDAC7HDAC2
SCHEMBL4091081 0.85 PPARD (0.43) PPARDPPARAPPARGHDAC3HDAC4
SCHEMBL1765886 0.85 PPARA (0.48) PPARDPPARAPPARG
SCHEMBL12648236 0.80 PPARA (0.53) PPARDPPARAPPARG
SCHEMBL12800547 0.80 PPARD (0.55) PPARDPPARAPPARG
SCHEMBL4095815 0.79 CRHR1 (0.40) PPARDPPARAPPARG

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090240058-A1 Activator for Peroxisome Proliferator-Activating Receptor Delta NIPPON CHEMIPHAR CO., LTD. (JP) 2009-09-24 US disclosed
EP-1854784-A1 ACTIVATOR FOR PEROXISOME PROLIFERATOR ACTIVATING RECEPTOR Nippon Chemiphar Co., Ltd. (JP) 2007-11-14 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090240058-A1 Activator for Peroxisome Proliferator-Activating Receptor Delta PPARG, PPARA, PPARD PPARD 3/4885PPARA 2/4885PPARG 1/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.