SCHEMBL4090763

SCHEMBL4090763

CCOC(=O)C(C)(C)Oc1ccc(C(=O)CCc2cc(-c3ccc(C(F)(F)F)cc3)nn2Cc2ccccc2)cc1C

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PPARD Q03181 9/20 0.42
PPARA Q07869 9/20 0.42
PPARG P37231 8/20 0.42
MAPT P10636 1/20 0.42
SMN1; SMN2 Q16637 2/20 0.42
TDP1 Q9NUW8 1/20 0.42
POLB P06746 1/20 0.41
HDAC1 Q13547 5/20 0.41
HDAC3 O15379 4/20 0.41
HDAC4 P56524 4/20 0.41
HDAC7 Q8WUI4 4/20 0.41
HDAC2 Q92769 4/20 0.41
HDAC10 Q969S8 4/20 0.41
HDAC11 Q96DB2 4/20 0.41
HDAC8 Q9BY41 4/20 0.41
HDAC6 Q9UBN7 4/20 0.41
HDAC9 Q9UKV0 4/20 0.41
HDAC5 Q9UQL6 4/20 0.41
NCOR2 Q9Y618 4/20 0.41
GPR119 Q8TDV5 3/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4089639 0.92 PPARD (0.49) PPARDPPARAPPARGHDAC1HDAC3
SCHEMBL4091081 0.87 PPARD (0.43) PPARDPPARAPPARGMAPTSMN1; SMN2
SCHEMBL4095815 0.87 CRHR1 (0.40) PPARDPPARAPPARG
SCHEMBL4105589 0.87 PPARA (0.39) PPARDPPARAPPARGHDAC1HDAC3
SCHEMBL4095560 0.85 PPARD (0.51) PPARDPPARAPPARG
SCHEMBL4100294 0.85 PPARD (0.40) PPARDPPARAPPARG
SCHEMBL4271873 0.83 HDAC1 (0.47) MAPTSMN1; SMN2TDP1POLBHDAC1
SCHEMBL4095867 0.80 PPARA (0.46) PPARDPPARAPPARG
SCHEMBL4095633 0.79 PPARD (0.45) PPARDPPARAPPARG
SCHEMBL5397707 0.79 PPARA (0.45) PPARDPPARAPPARGMAPTSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090240058-A1 Activator for Peroxisome Proliferator-Activating Receptor Delta NIPPON CHEMIPHAR CO., LTD. (JP) 2009-09-24 US disclosed
EP-1854784-A1 ACTIVATOR FOR PEROXISOME PROLIFERATOR ACTIVATING RECEPTOR Nippon Chemiphar Co., Ltd. (JP) 2007-11-14 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090240058-A1 Activator for Peroxisome Proliferator-Activating Receptor Delta PPARG, PPARA, PPARD PPARD 3/4885PPARA 2/4885PPARG 1/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.