Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 4/20 | 0.66 |
| ▸ | AGTR2 | P50052 | 3/20 | 0.66 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.66 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.66 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.66 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Losartan SCHEMBL7420948 | 1.00 | AGTR1 (0.66) | AGTR1AGTR2ABCC4ABCB11PDE3B | |
| Losartan SCHEMBL42080 | 1.00 | AGTR1 (0.66) | AGTR1AGTR2ABCC4ABCB11PDE3B | |
| Losartan SCHEMBL6684517 | 0.99 | AGTR1 (0.65) | AGTR1AGTR2ABCC4ABCB11PDE3B | |
| Losartan SCHEMBL6684460 | 0.99 | AGTR1 (0.65) | AGTR1AGTR2ABCC4ABCB11PDE3B | |
| Losartan SCHEMBL28493004 | 0.99 | AGTR1 (0.65) | AGTR1AGTR2ABCC4ABCB11PDE3B | |
| Losartan SCHEMBL60 | 0.99 | AGTR1 (0.67) | AGTR1AGTR2ABCC4ABCB11PDE3B | |
| Losartan SCHEMBL29383742 | 0.99 | AGTR1 (0.67) | AGTR1AGTR2ABCC4ABCB11PDE3B | |
| Losartan SCHEMBL6092394 | 0.99 | AGTR1 (0.67) | AGTR1AGTR2ABCC4ABCB11PDE3B | |
| Losartan SCHEMBL4726128 | 0.98 | AGTR1 (0.66) | AGTR1AGTR2ABCC4ABCB11PDE3B | |
| Losartan SCHEMBL3216357 | 0.98 | AGTR1 (0.66) | AGTR1AGTR2ABCC4ABCB11PDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090076281-A1 | PROCESS FOR THE PREPARATION OF LOSARTAN AND ITS SALTS | MEDICHEM, S.A. (ES) | 2009-03-19 | — | — | US | disclosed |
| EP-1891055-A2 | PROCESS FOR THE PREPARATION OF LOSARTAN POTASSIUM | Medichem, S.A. (ES) | 2008-02-27 | — | — | EP | disclosed |
| WO-2007020533-A2 | PROCESS FOR THE PREPARATION OF LOSARTAN POTASSIUM | MEDICHEM, S.A. (US) | 2007-02-22 | — | — | WO | disclosed |