Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NCEH1 | Q6PIU2 | 3/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | UGT2B7 | P16662 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2720285 | 0.82 | NCEH1 (0.38) | NCEH1POLBUGT2B7 | |
| SCHEMBL4099395 | 0.76 | TDP1 (0.40) | POLBNPC1 | |
| SCHEMBL30121106 | 0.71 | POLB (0.35) | NCEH1POLB | |
| SCHEMBL15445446 | 0.71 | POLB (0.35) | NCEH1POLB | |
| SCHEMBL2012785 | 0.68 | POLB (0.52) | NCEH1POLBUGT2B7HSD17B10NPC1 | |
| SCHEMBL2720195 | 0.65 | NCEH1 (0.38) | NCEH1POLBNPC1MAPTRAB9A | |
| SCHEMBL14038619 | 0.64 | KDM4E (0.42) | POLBMAPTRAB9ASMN1; SMN2 | |
| SCHEMBL4355031 | 0.62 | RECQL (0.36) | NCEH1POLBUGT2B7 | |
| Methyl Alcohol SCHEMBL28700048 | 0.61 | POLB (0.52) | NCEH1POLBHSD17B10MAPT | |
| SCHEMBL14381324 | 0.61 | POLB (0.38) | POLBHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012061696-A1 | 5 -CYANO-4, 6 -DIAMINOPYRIMIDINE OR 6 -AMINOPURINE DERIVATIVES AS PI3K- DELTA INHIBITORS | AMGEN INC. (US) | 2012-05-10 | — | — | WO | disclosed |