Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | HTT | P42858 | 3/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | CASP7 | P55210 | 1/20 | 0.33 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2729617 | 0.85 | TDP1 (0.38) | TDP1LMNATP53MAPK1NPSR1 | |
| SCHEMBL4091324 | 0.76 | NCEH1 (0.38) | POLBNPC1 | |
| SCHEMBL2729350 | 0.72 | ALDH1A1 (0.33) | TDP1LMNATP53MAPK1NPSR1 | |
| SCHEMBL2730524 | 0.71 | NPSR1 (0.39) | TDP1LMNATP53MAPK1NPSR1 | |
| SCHEMBL6923510 | 0.67 | POLB (0.49) | TDP1LMNAALDH1A1POLBGAA | |
| SCHEMBL6923507 | 0.67 | POLB (0.49) | TDP1LMNAALDH1A1POLBGAA | |
| SCHEMBL31706143 | 0.64 | LMNA (0.47) | TDP1LMNATP53MAPK1NPSR1 | |
| SCHEMBL2002901 | 0.64 | LMNA (0.47) | TDP1LMNATP53MAPK1NPSR1 | |
| SCHEMBL2002904 | 0.64 | LMNA (0.47) | TDP1LMNATP53MAPK1NPSR1 | |
| SCHEMBL14729729 | 0.64 | LMNA (0.47) | TDP1LMNATP53MAPK1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012061696-A1 | 5 -CYANO-4, 6 -DIAMINOPYRIMIDINE OR 6 -AMINOPURINE DERIVATIVES AS PI3K- DELTA INHIBITORS | AMGEN INC. (US) | 2012-05-10 | — | — | WO | disclosed |