Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FYN | P06241 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | SYK | P43405 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.33 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | EDNRB | P24530 | 3/20 | 0.33 |
| ▸ | EDNRA | P25101 | 3/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | FLT3 | P36888 | 1/20 | 0.33 |
| ▸ | IDO1 | P14902 | 1/20 | 0.33 |
| ▸ | TDO2 | P48775 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Isothiazole SCHEMBL3984653 | 0.87 | FYN (0.34) | FYNNPC1RAB9ASMN1; SMN2KMT2A | |
| SCHEMBL615948 | 0.78 | FYN (0.37) | FYNNPC1RAB9ASMN1; SMN2KMT2A | |
| SCHEMBL618081 | 0.76 | KMT2A (0.37) | FYNNPC1RAB9ASMN1; SMN2SYK | |
| SCHEMBL1168409 | 0.72 | KMT2A (0.37) | FYNNPC1RAB9ASMN1; SMN2SYK | |
| SCHEMBL1168072 | 0.72 | KMT2A (0.38) | FYNNPC1RAB9ASMN1; SMN2KMT2A | |
| SCHEMBL10189256 | 0.70 | FYN (0.33) | FYNNPC1RAB9ASMN1; SMN2KMT2A | |
| Isothiazole SCHEMBL3987853 | 0.70 | TUBB4A (0.34) | FYNSMN1; SMN2KDM4EALDH1A1HPGD | |
| Isothiazole SCHEMBL3981927 | 0.69 | NEK2 (0.38) | SMN1; SMN2KMT2AMEN1MAPTKDM4E | |
| Isothiazole SCHEMBL3981672 | 0.68 | SMN1; SMN2 (0.35) | NPC1RAB9ASMN1; SMN2KMT2AMEN1 | |
| SCHEMBL412031 | 0.68 | SMN1; SMN2 (0.42) | FYNNPC1RAB9ASMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2059250-A2 | COMPOUNDS FOR THE TREATMENT OF ANGIOGENESIS | Synta Pharmaceuticals Corporation (US) | 2009-05-20 | — | — | EP | disclosed |
| WO-2008033449-A2 | COMPOUNDS FOR THE TREATMENT OF ANGIOGENESIS | SYNTA PHARMACEUTICALS CORP. (US) | 2008-03-20 | — | — | WO | disclosed |