Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.49 |
| ▸ | APAF1 | O14727 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.41 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7068103 | 0.86 | ALDH1A1 (0.53) | SMN1; SMN2ALDH1A1NPSR1MAPK1HTT | |
| SCHEMBL21258377 | 0.82 | ALDH1A1 (0.64) | SMN1; SMN2HPGDL3MBTL1ALDH1A1NPSR1 | |
| SCHEMBL27971875 | 0.77 | ADORA2A (0.47) | SMN1; SMN2HPGDALDH1A1NPSR1MAPK1 | |
| SCHEMBL9775493 | 0.77 | KDM4E (0.58) | SMN1; SMN2ALDH1A1MAPK1IMPDH2MAPT | |
| SCHEMBL15125374 | 0.77 | KDR (0.49) | SMN1; SMN2HPGDALDH1A1NPSR1MAPK1 | |
| SCHEMBL89446 | 0.76 | SMN1; SMN2 (0.58) | SMN1; SMN2POLBL3MBTL1ALDH1A1MAPK1 | |
| SCHEMBL26242537 | 0.75 | MAPT (0.43) | SMN1; SMN2APAF1HPGDRECQLPOLB | |
| SCHEMBL27966692 | 0.75 | TAAR1 (0.46) | SMN1; SMN2HPGDALDH1A1NPSR1MAPK1 | |
| Ammonia Solution, Strong SCHEMBL27658861 | 0.73 | SMN1; SMN2 (0.56) | SMN1; SMN2POLBL3MBTL1ALDH1A1MAPK1 | |
| Ammonia Solution, Strong SCHEMBL17728179 | 0.72 | SMN1; SMN2 (0.47) | SMN1; SMN2ALDH1A1MAPK1IMPDH2MAPK11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090239872-A1 | TREATMENT OF MESOTHELIOMA | HOHNEKER JOHN ARTHUR | 2009-09-24 | — | — | US | disclosed |
| US-20090196871-A1 | USE OF 4-PYRIDYLMETHYLPHTHALAZINES FOR CANCER TREATMENT | DUGAN MARGARET HAN | 2009-08-06 | — | — | US | disclosed |
| US-20060058313-A1 | Treatment of mesothelioma | HOHNEKER JOHN A | 2006-03-16 | — | — | US | disclosed |
| US-20040258770-A1 | Use of 4-pyridylmethylphthalazines for cancer treatment | DUGAN MARGARET HAN (US) | 2004-12-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090239872-A1 | TREATMENT OF MESOTHELIOMA | CD47, MB, MGMT | SMN1; SMN2 1723/4885APAF1 1495/4885HPGD 506/4885 |
| US-20060058313-A1 | Treatment of mesothelioma | CD47, MB, MGMT | SMN1; SMN2 1723/4885APAF1 1495/4885HPGD 506/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.