Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | HPGD | P15428 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | CCKBR | P32239 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.44 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17819292 | 0.80 | CYP1A2 (0.60) | CYP1A2ALDH1A1HTTGAAKMT2A | |
| SCHEMBL4232792 | 0.80 | ALDH1A1 (0.65) | CYP1A2ALDH1A1HPGDLMNAKDM4E | |
| SCHEMBL5757614 | 0.77 | NOTUM (0.56) | CYP1A2ALDH1A1HPGDHTTGAA | |
| SCHEMBL29223912 | 0.76 | CYP1A2 (0.61) | CYP1A2ALDH1A1HTTGAAKMT2A | |
| SCHEMBL11608471 | 0.74 | KMT2A (0.60) | ALDH1A1HPGDLMNAHTTGAA | |
| SCHEMBL5930954 | 0.74 | PLA2G10 (0.50) | CYP1A2HTTGAACCKBRKMT2A | |
| SCHEMBL17537376 | 0.73 | CYP1A2 (0.58) | CYP1A2ALDH1A1HTTGAAKMT2A | |
| SCHEMBL15353284 | 0.73 | PLA2G10 (0.59) | CYP1A2ALDH1A1HPGDKMT2ANOTUM | |
| SCHEMBL11125616 | 0.73 | ALDH1A1 (0.51) | ALDH1A1HPGDLMNAKDM4EGAA | |
| SCHEMBL4059567 | 0.72 | ALDH1A1 (0.52) | CYP1A2ALDH1A1HPGDLMNAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2104665-A2 | IMIDAZOLONE AND IMIDAZOLIDINONE DERIVATIVES AS 11B-HSD1 INHIBITORS FOR DIABETES | F. Hoffmann-Roche AG (CH) | 2009-09-30 | — | — | EP | claimed |
| WO-2008046758-A2 | IMIDAZOLONE AND IMIDAZOLIDINONE DERIVATIVES AS 11B-HSD1 INHIBITORS FOR DIABETES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-04-24 | — | — | WO | claimed |
| EP-2104665-A2 | IMIDAZOLONE AND IMIDAZOLIDINONE DERIVATIVES AS 11B-HSD1 INHIBITORS FOR DIABETES | F. Hoffmann-Roche AG (CH) | 2009-09-30 | — | — | EP | disclosed |
| WO-2008046758-A2 | IMIDAZOLONE AND IMIDAZOLIDINONE DERIVATIVES AS 11B-HSD1 INHIBITORS FOR DIABETES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-04-24 | — | — | WO | disclosed |
| EP-0051829-B1 | N-SUBSTITUTED OMEGA-(2-OXO-4-IMIDAZOLIN-1-YL) ALCANOIC ACIDS, SALTS AND ESTERS THEREOF, PROCESS FOR PRODUCING THE SAME AND THESE ACTIVE AGENTS CONTAINING PHARMACEUTICAL COMPOUNDS | A. Nattermann & Cie. GmbH (DE) | 1984-12-05 | — | — | EP | disclosed |
| US-4349684-A | ANTIALLERGENS, ANTIASTHMATICS | A. NATTERMANN & CIE GMBH (DE) | 1982-09-14 | — | — | US | disclosed |
| EP-0051829-A1 | N-substituted omega-(2-oxo-4-imidazolin-1-yl) alcanoic acids, salts and esters thereof, process for producing the same and these active agents containing pharmaceutical compounds | A. Nattermann & Cie. GmbH (DE) | 1982-05-19 | — | — | EP | disclosed |