Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.52 |
| ▸ | HPGD | P15428 | 4/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | RAD51 | Q06609 | 1/20 | 0.48 |
| ▸ | RPA1 | P27694 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4053051 | 0.83 | ALDH1A1 (0.60) | ALDH1A1HPGDKDM4ELMNAGAA | |
| SCHEMBL4232792 | 0.80 | ALDH1A1 (0.65) | ALDH1A1HPGDKDM4ELMNAGAA | |
| SCHEMBL11126289 | 0.76 | ALDH1A1 (0.69) | ALDH1A1HPGDKDM4ELMNAGAA | |
| SCHEMBL11123802 | 0.76 | MAPK1 (0.69) | ALDH1A1HPGDKDM4ELMNAGAA | |
| SCHEMBL11125616 | 0.76 | ALDH1A1 (0.51) | ALDH1A1HPGDKDM4ELMNAGAA | |
| SCHEMBL11124324 | 0.73 | KMT2A (0.52) | ALDH1A1HPGDLMNARPA1GAA | |
| SCHEMBL4093082 | 0.72 | CYP1A2 (0.51) | ALDH1A1HPGDKDM4ELMNATP53 | |
| SCHEMBL5755545 | 0.71 | HPGD (0.48) | ALDH1A1HPGDKDM4ELMNATP53 | |
| SCHEMBL11608487 | 0.71 | TP53 (0.53) | ALDH1A1KDM4ETP53RAD51GAA | |
| SCHEMBL31576799 | 0.68 | TP53 (0.49) | ALDH1A1LMNATP53RAD51MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7553862-B2 | 4-amino-1,5-substituted-1,5-dihydro-imidazol-2-ones | HOFFMANN-LA ROCHE INC. (US) | 2009-06-30 | — | — | US | disclosed |
| US-7553862-B2 | 4-amino-1,5-substituted-1,5-dihydro-imidazol-2-ones | HOFFMANN-LA ROCHE INC. (US) | 2009-06-30 | — | — | US | disclosed |
| US-7553862-B2 | 4-amino-1,5-substituted-1,5-dihydro-imidazol-2-ones | HOFFMANN-LA ROCHE INC. (US) | 2009-06-30 | — | — | US | disclosed |
| WO-2007101802-A1 | 4-AMINO-1,5-SUBSTITUTED 1,5-DIHYDRO-IMIDAZOL-2-ONES | F. HOFFMANN-LA ROCHE AG (CH) | 2007-09-13 | — | — | WO | disclosed |
| US-20070213384-A1 | 4-Amino-1,5-substituted-1,5-dihydro-imidazol-2-ones | F. HOFFMANN-LA ROCHE AG (CH) | 2007-09-13 | — | — | US | disclosed |
| US-20070213384-A1 | 4-Amino-1,5-substituted-1,5-dihydro-imidazol-2-ones | F. HOFFMANN-LA ROCHE AG (CH) | 2007-09-13 | — | — | US | disclosed |
| US-20070213384-A1 | 4-Amino-1,5-substituted-1,5-dihydro-imidazol-2-ones | F. HOFFMANN-LA ROCHE AG (CH) | 2007-09-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070213384-A1 | 4-Amino-1,5-substituted-1,5-dihydro-imidazol-2-ones | SLC1A2, SLC6A5, SLC1A1 | ALDH1A1 697/4885HPGD 2553/4885KDM4E 4091/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.