Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP4F2 | P78329 | 1/20 | 0.39 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.39 |
| ▸ | PTGER4 | P35408 | 13/20 | 0.37 |
| ▸ | PTGER2 | P43116 | 12/20 | 0.37 |
| ▸ | PTGER3 | P43115 | 5/20 | 0.37 |
| ▸ | PTGER1 | P34995 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4301619 | 0.85 | CYP4F2 (0.41) | CYP4F2CYP4A11PTGER4PTGER2PTGER3 | |
| SCHEMBL4300961 | 0.79 | CYP4F2 (0.47) | CYP4F2CYP4A11PTGER4PTGER2PTGER3 | |
| SCHEMBL4551977 | 0.71 | HRH1 (0.42) | CYP4F2CYP4A11ALDH1A1HPGD | |
| SCHEMBL4300107 | 0.71 | HRH1 (0.42) | CYP4F2CYP4A11ALDH1A1HPGD | |
| SCHEMBL4080955 | 0.69 | PTGER4 (0.39) | CYP4F2CYP4A11PTGER4PTGER2PTGER3 | |
| SCHEMBL3980166 | 0.69 | PTGER4 (0.39) | CYP4F2CYP4A11PTGER4PTGER2PTGER3 | |
| SCHEMBL3984251 | 0.69 | PTGER4 (0.35) | CYP4F2CYP4A11PTGER4PTGER2PTGER3 | |
| SCHEMBL4300863 | 0.69 | PTGER4 (0.35) | CYP4F2CYP4A11PTGER4PTGER2PTGER3 | |
| SCHEMBL4106475 | 0.68 | PTGER4 (0.34) | PTGER4PTGER2PTGER3PTGER1 | |
| SCHEMBL6900287 | 0.67 | CYP4A11 (0.71) | CYP4F2CYP4A11ALDH1A1HPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1912957-A4 | EP4 RECEPTOR AGONIST, COMPOSITIONS AND METHODS THEREOF | MERCK FROSST CANADA LTD (CA) | 2009-05-13 | — | — | EP | disclosed |
| EP-1912957-A1 | EP4 RECEPTOR AGONIST, COMPOSITIONS AND METHODS THEREOF | Merck Frosst Canada Ltd. (CA) | 2008-04-23 | — | — | EP | disclosed |
| WO-2007014462-A1 | EP4 RECEPTOR AGONIST, COMPOSITIONS AND METHODS THEREOF | MERCK FROSST CANADA LTD. (CA) | 2007-02-08 | — | — | WO | disclosed |