Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 10/20 | 0.68 |
| ▸ | CYP2C9 | P11712 | 6/20 | 0.68 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 6/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.34 |
| ▸ | AKR1C3 | P42330 | 4/20 | 0.33 |
| ▸ | AKR1C2 | P52895 | 4/20 | 0.33 |
| ▸ | AKR1C1 | Q04828 | 2/20 | 0.33 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.33 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.33 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.32 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.31 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.31 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.31 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.31 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.31 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.31 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1374496 | 0.81 | APP (1.00) | APPCYP2C9CYP3A4CYP2C19CYP2D6 | |
| SCHEMBL5479423 | 0.75 | APP (0.84) | APPCYP2C9CYP3A4CYP2C19CYP2D6 | |
| SCHEMBL1134058 | 0.70 | APP (0.60) | APPCYP2C9CYP3A4CYP2C19CYP2D6 | |
| SCHEMBL15741094 | 0.69 | FAAH (0.48) | APPCYP2C9 | |
| SCHEMBL1371389 | 0.68 | APP (0.80) | APPCYP2C9CYP3A4CYP2C19CYP2D6 | |
| SCHEMBL1373512 | 0.66 | APP (1.00) | APPCYP2C9CYP3A4CYP2C19CYP2D6 | |
| SCHEMBL1374640 | 0.66 | APP (0.79) | APPCYP2C9CYP3A4CYP2C19CYP2D6 | |
| SCHEMBL3936259 | 0.65 | APP (0.90) | APPCYP2C9CYP3A4CYP2C19CYP2D6 | |
| SCHEMBL15741120 | 0.63 | APP (0.54) | APPCYP2C9 | |
| SCHEMBL3942347 | 0.63 | APP (0.92) | APPCYP2C9CYP3A4CYP2C19CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7531692-B2 | Derivatives of 1-phenylalkanecarboxylic acids for the treatment of neurodegenerative diseases | CHIESI FARMACEUTICI S.P.A. (IT) | 2009-05-12 | — | — | US | disclosed |
| EP-1778623-B1 | DERIVATIVES OF 1-PHENYLALKANECARBOXYLIC ACIDS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | CHIESI FARMA SPA (IT) | 2008-07-02 | — | — | EP | disclosed |
| US-20080096968-A1 | Derivatives of 1-Phenylalkanecarboxylic Acids for the Treatment of Neurodegenerative Diseases | CHIESI FARMACEUTICI S.P.A. (IT) | 2008-04-24 | — | — | US | disclosed |
| EP-1778623-A2 | DERIVATIVES OF 1-PHENYLALKANECARBOXYLIC ACIDS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | CHIESI FARMACEUTICI S.p.A. (IT) | 2007-05-02 | — | — | EP | disclosed |
| WO-2006016219-A2 | DERIVATIVES OF 1-PHENYLALKANECARBOXYLIC ACIDS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | CHIESI FARMACEUTICI S.P.A. (IT) | 2006-02-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080096968-A1 | Derivatives of 1-Phenylalkanecarboxylic Acids for the Treatment of Neurodegenerative Diseases | PSEN1, SNCA, PSEN2 | APP 5/4885CYP2C9 2957/4885CYP3A4 2993/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.