Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 6/20 | 0.60 |
| ▸ | AKR1C3 | P42330 | 5/20 | 0.60 |
| ▸ | AKR1C2 | P52895 | 5/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.60 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.60 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.60 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.60 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.60 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.60 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.60 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.60 |
| ▸ | AKR1C1 | Q04828 | 3/20 | 0.41 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.41 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | AHR | P35869 | 3/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.35 |
| ▸ | PGR | P06401 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL700240 | 0.81 | SLC6A4 (0.42) | — | |
| SCHEMBL20018243 | 0.81 | APP (0.62) | APPAKR1C3AKR1C2CYP2C19CYP3A4 | |
| SCHEMBL12050459 | 0.76 | APP (0.63) | APPAKR1C3AKR1C2CYP2C19CYP3A4 | |
| SCHEMBL28268518 | 0.75 | SLC6A4 (0.47) | — | |
| SCHEMBL407631 | 0.75 | APP (1.00) | APPAKR1C3AKR1C2CYP2C19CYP3A4 | |
| SCHEMBL29926966 | 0.75 | APP (1.00) | APPAKR1C3AKR1C2CYP2C19CYP3A4 | |
| SCHEMBL15307670 | 0.74 | APP (0.79) | APPAKR1C3AKR1C2CYP2C19CYP3A4 | |
| SCHEMBL1133859 | 0.73 | APP (0.59) | APPAKR1C3AKR1C2CYP2C19CYP3A4 | |
| SCHEMBL16321554 | 0.71 | KDM1A (0.33) | APPCYP2C19CYP3A4CYP2C9 | |
| SCHEMBL4093578 | 0.70 | APP (0.68) | APPAKR1C3AKR1C2CYP2C19CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015181094-A1 | 1-(2-FLUOROBIPHENYL-4-YL)-CYCLOPROPANECARBOXYLIC ACID DERIVATIVES FOR THE TREATMENT OF DOWN'S SYNDROME | CHIESI FARMACEUTICI S.P.A. (IT) | 2015-12-03 | — | — | WO | disclosed |
| US-20150335596-A1 | 1-(2-FLUOROBIPHENYL-4-YL)-CYCLOPROPANECARBOXYLIC ACID DERIVATIVES FOR THE TREATMENT OF DOWN'S SYNDROME | CHIESI FARMACEUTICI S.P.A. (IT) | 2015-11-26 | — | — | US | disclosed |
| US-9056818-B2 | Process for the preparation of derivatives of 1-(2-halobiphenyl-4-yl)-cyclopropanecarboxylic acid | CHIESI FARMACEUTICI S.P.A. (IT) | 2015-06-16 | — | — | US | disclosed |
| EP-2834214-A1 | DERIVATIVES OF 1-(2-HALO-BIPHENYL-4-YL)- ALKANECARBOXYLIC ACIDS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | Chiesi Farmaceutici S.p.A. (IT) | 2015-02-11 | — | — | EP | disclosed |
| US-8835494-B2 | Derivatives of 1-(2-halo-biphenyl-4-yl)-Alkanecarboxylic for the treatment of neurodegenerative diseases | CHIESI FARMACEUTICI S.P.A. (IT) | 2014-09-16 | — | — | US | disclosed |
| EP-2462098-B1 | PROCESS FOR THE PREPARATION OF DERIVATIVES OF 1-(2-HALOBIPHENYL-4-YL)-CYCLOPROPANECARBOXYLIC ACID | CHIESI FARMA SPA (IT) | 2013-10-23 | — | — | EP | disclosed |
| WO-2013150072-A1 | DERIVATIVES OF 1-(2-HALO-BIPHENYL-4-YL)- ALKANECARBOXYLIC ACIDS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | CHIESI FARMACEUTICI S.P.A. (IT) | 2013-10-10 | — | — | WO | disclosed |
| US-20130267592-A1 | DERIVATIVES OF 1-(2-HALO-BIPHENYL-4-YL)-ALKANECARBOXYLIC ACIDS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | CHIESI FARMACEUTICI S.P.A. (IT) | 2013-10-10 | — | — | US | disclosed |
| EP-2462098-A2 | PROCESS FOR THE PREPARATION OF DERIVATIVES OF 1-(2-HALOBIPHENYL-4-YL)-CYCLOPROPANECARBOXYLIC ACID | Chiesi Farmaceutici S.p.A. (IT) | 2012-06-13 | — | — | EP | disclosed |
| US-8076505-B2 | Process of preparing derivatives of 1-(2-halobiphenyl-4-yl)-cyclopropanecarboxylic acid | CHIESI FARMACEUTICI S.P.A. (IT) | 2011-12-13 | — | — | US | disclosed |
| EP-2285765-A1 | PROCESS OF PREPARING DERIVATIVES OF 1-(2-HALOBIPHENYL-4-YL)-CYCLOPROPANECARBOXYLIC ACID | CHIESI FARMACEUTICI S.p.A. (IT) | 2011-02-23 | — | — | EP | disclosed |
| WO-2009149797-A1 | PROCESS OF PREPARING DERIVATIVES OF 1-(2-HALOBIPHENYL-4-YL)-CYCLOPROPANECARBOXYLIC ACID | CHIESI FARMACEUTICI S.P.A. (IT) | 2009-12-17 | — | — | WO | disclosed |
| US-20090312426-A1 | PROCESS OF PREPARING DERIVATIVES OF 1-(2-HALOBIPHENYL-4-YL)-CYCLOPROPANECARBOXYLIC ACID | CHIESI FARMACEUTICI S.P.A. (IT) | 2009-12-17 | — | — | US | disclosed |
| EP-2133322-A1 | Process of preparing derivatives of 1-(2-halobiphenyl-4-yl)-cyclopropanecarboxylic acid | CHIESI FARMACEUTICI S.p.A. (IT) | 2009-12-16 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150335596-A1 | 1-(2-FLUOROBIPHENYL-4-YL)-CYCLOPROPANECARBOXYLIC ACID DERIVATIVES FOR THE TREATMENT OF DOWN'S SYNDROME | CALM1, IQGAP1, FKBP4 | APP 755/4885AKR1C3 1699/4885AKR1C2 1216/4885 |
| US-20090312426-A1 | PROCESS OF PREPARING DERIVATIVES OF 1-(2-HALOBIPHENYL-4-YL)-CYCLOPROPANECARBOXYLIC ACID | CYP51A1, DHPS, CYP8B1 | APP 4370/4885AKR1C3 161/4885AKR1C2 170/4885 |
| US-20130267592-A1 | DERIVATIVES OF 1-(2-HALO-BIPHENYL-4-YL)-ALKANECARBOXYLIC ACIDS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | HTT, PSEN1, PSEN2 | APP 6/4885AKR1C3 712/4885AKR1C2 699/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.