Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.42 |
| ▸ | DYRK3 | O43781 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 6/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.37 |
| ▸ | PIM1 | P11309 | 1/20 | 0.37 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.37 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.37 |
| ▸ | CLK1 | P49759 | 1/20 | 0.37 |
| ▸ | CLK3 | P49761 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL4093780 | 1.00 | TRPV1 (0.42) | TRPV1DYRK3RAB9AKDM4ENPC1 | |
| SCHEMBL2993432 | 0.95 | DYRK3 (0.42) | TRPV1DYRK3RAB9AKDM4ENPC1 | |
| SCHEMBL2993435 | 0.95 | DYRK3 (0.42) | TRPV1DYRK3RAB9AKDM4ENPC1 | |
| Trifluoroacetic Acid SCHEMBL4091117 | 0.90 | OGA (0.39) | DYRK3TP53ALDH1A1MAPTGAA | |
| Trifluoroacetic Acid SCHEMBL4091128 | 0.90 | OGA (0.39) | DYRK3TP53ALDH1A1MAPTGAA | |
| Trifluoroacetic Acid SCHEMBL4093888 | 0.89 | OGA (0.40) | DYRK3TP53ALDH1A1MAPTPIK3CD | |
| Trifluoroacetic Acid SCHEMBL4093894 | 0.89 | OGA (0.40) | DYRK3TP53ALDH1A1MAPTPIK3CD | |
| Trifluoroacetic Acid SCHEMBL4095087 | 0.86 | PABPC1 (0.48) | DYRK3RAB9ANPC1SMN1; SMN2ALDH1A1 | |
| Trifluoroacetic Acid SCHEMBL4095081 | 0.86 | PABPC1 (0.48) | DYRK3RAB9ANPC1SMN1; SMN2ALDH1A1 | |
| Trifluoroacetic Acid SCHEMBL4089999 | 0.86 | DYRK3 (0.38) | DYRK3RAB9ANPC1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090203692-A1 | NOVEL CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION | 2009-08-13 | — | — | US | disclosed |
| EP-1885362-A2 | NOVEL CHEMICAL COMPOUNDS | Smithkline Beecham Corporation (US) | 2008-02-13 | — | — | EP | disclosed |
| WO-2006127458-A2 | NOVEL CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2006-11-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090203692-A1 | NOVEL CHEMICAL COMPOUNDS | HIPK3, HIPK1, HIPK4 | TRPV1 4429/4885DYRK3 1471/4885RAB9A 1181/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.