Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.51 |
| ▸ | CACNA1H | O95180 | 2/20 | 0.50 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.50 |
| ▸ | PTGDR2 | Q9Y5Y4 | 5/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.45 |
| ▸ | CCR1 | P32246 | 1/20 | 0.44 |
| ▸ | CCR2 | P41597 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3045528 | 0.80 | TDP1 (0.54) | TDP1L3MBTL1CACNA1HCACNA1BPTGDR2 | |
| SCHEMBL3274401 | 0.79 | POLB (0.72) | TDP1L3MBTL1CACNA1HCACNA1BPTGDR2 | |
| SCHEMBL2897956 | 0.79 | CCR1 (0.60) | TDP1L3MBTL1CACNA1HCACNA1BPTGDR2 | |
| SCHEMBL16613203 | 0.78 | NPC1 (0.51) | TDP1KMT2ALMNAHTTNPC1 | |
| Hydrochloric Acid SCHEMBL16597575 | 0.77 | NPC1 (0.50) | TDP1KMT2ALMNAHTTNPC1 | |
| SCHEMBL3049525 | 0.77 | CACNA1H (0.56) | TDP1L3MBTL1CACNA1HCACNA1BPTGDR2 | |
| SCHEMBL4043636 | 0.77 | PTGDR2 (0.57) | TDP1L3MBTL1CACNA1HCACNA1BPTGDR2 | |
| SCHEMBL8752434 | 0.76 | FFAR1 (0.65) | TDP1L3MBTL1CACNA1HCACNA1BPTGDR2 | |
| SCHEMBL3757218 | 0.76 | POLB (0.55) | TDP1L3MBTL1CACNA1HCACNA1BPTGDR2 | |
| SCHEMBL3752373 | 0.75 | CACNA1H (0.49) | TDP1L3MBTL1CACNA1HCACNA1BPTGDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2057116-A1 | NEW PHENYLSULFAMOYL BENZAMIDE DERIVATIVES AS BRADYKININ ANTAGONISTS | Richter Gedeon NYRT (HU) | 2009-05-13 | — | — | EP | disclosed |
| WO-2008050167-A1 | NEW PHENYLSULFAMOYL BENZAMIDE DERIVATIVES AS BRADYKININ ANTAGONISTS | RICHTER GEDEON NYRT. (HU) | 2008-05-02 | — | — | WO | disclosed |