Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | ABL1 | P00519 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.43 |
| ▸ | TTR | P02766 | 1/20 | 0.43 |
| ▸ | PGR | P06401 | 1/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HSPA5 | P11021 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | CBR1 | P16152 | 1/20 | 0.43 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11631790 | 0.85 | CA1 (0.50) | KDM4EALDH1A1TSHRHSD17B10LMNA | |
| SCHEMBL4098055 | 0.78 | IDO1 (0.47) | KDM4ETDP1LMNAMAPTHPGD | |
| SCHEMBL32662867 | 0.77 | CA12 (0.67) | KDM4EPKMRXFP1ALDH1A1TSHR | |
| SCHEMBL1058422 | 0.77 | CA12 (0.67) | KDM4EPKMRXFP1ALDH1A1TSHR | |
| SCHEMBL10374433 | 0.77 | NPC1 (0.61) | ALDH1A1TSHRHSD17B10TDP1CYP3A4 | |
| SCHEMBL11714480 | 0.76 | ABL1 (0.50) | KDM4EALDH1A1TSHRHSD17B10TDP1 | |
| SCHEMBL2956458 | 0.75 | HSD17B10 (0.50) | KDM4EPKMRXFP1ALDH1A1TSHR | |
| SCHEMBL27827654 | 0.73 | ACMSD (0.56) | KDM4EALDH1A1HSD17B10LMNAHSP90AA1 | |
| SCHEMBL212176 | 0.71 | LMNA (0.57) | KDM4EALDH1A1TSHRHSD17B10LMNA | |
| SCHEMBL31142480 | 0.71 | MAPT (0.59) | ALDH1A1TSHRHSD17B10TDP1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090029975-A1 | 1,3-BENZOTHIAZINONE DERIVATIVE AND USE THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-01-29 | — | — | US | disclosed |
| EP-1897880-A1 | 1,3-BENZOTHIAZINONE DERIVATIVE AND USE THEREOF | Takeda Pharmaceutical Company Limited (JP) | 2008-03-12 | — | — | EP | disclosed |
| EP-0530207-A1 | IMIDAZOPYRIDINE PAF ANTAGONISTS | Pfizer Limited (GB) | 1993-03-10 | — | — | EP | disclosed |
| WO-1991017162-A1 | IMIDAZOPYRIDINE PAF ANTAGONISTS | PFIZER LIMITED (GB) | 1991-11-14 | — | — | WO | disclosed |
| US-4082770-A | ANALGESIC, ANTIPYRETIC, ANTIINFLAMMATORY | WARNER-LAMBERT COMPANY (US) | 1978-04-04 | — | — | US | disclosed |
| US-4056526-A | ANALGESIC, ANTIPYRETIC, ANTIINFLAMMATORY | WARNER-LAMBERT COMPANY (US) | 1977-11-01 | — | — | US | disclosed |
| US-4018793-A | ANALGESICS, ANTIINFLAMMATORY, ANTIPYRETICS | WARNER-LAMBERT COMPANY (US) | 1977-04-19 | — | — | US | disclosed |
| US-3971814-A | ANALGESICS, ANTIPYRETICS, ANTIINFLAMMATORY AGENTS | WARNER-LAMBERT COMPANY (US) | 1976-07-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090029975-A1 | 1,3-BENZOTHIAZINONE DERIVATIVE AND USE THEREOF | MIF, CCL2, MSR1 | KDM4E 3212/4885PKM 2187/4885RXFP1 1468/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.