SCHEMBL4094280

SCHEMBL4094280

CCCCN(C(=O)Nc1cc(C(N)=O)c(F)cc1F)C1CCN(Cc2ccc(Oc3ccc(NS(C)(=O)=O)cc3)nc2C2CC2)CC1

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CDK2 P24941 2/20 0.37
CDK8 P49336 2/20 0.37
CDK1 P06493 1/20 0.37
UBE2M P61081 7/20 0.37
DCUN1D1 Q96GG9 7/20 0.37
MCHR1 Q99705 4/20 0.36
ALDH1A1 P00352 1/20 0.35
LMNA P02545 1/20 0.35
PTBP1 P26599 1/20 0.35
TRPV1 Q8NER1 5/20 0.34
STK25 O00506 1/20 0.33
CIT O14578 1/20 0.33
MAP2K7 O14733 1/20 0.33
IKBKB O14920 1/20 0.33
AURKA O14965 1/20 0.33
GAK O14976 1/20 0.33
CHUK O15111 1/20 0.33
MUSK O15146 1/20 0.33
MAPK13 O15264 1/20 0.33
MAP3K13 O43283 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL843230 0.94 CDK2 (0.37) CDK2CDK8CDK1UBE2MDCUN1D1
SCHEMBL2250983 0.93 MCHR1 (0.38) CDK2CDK8CDK1UBE2MDCUN1D1
Hydrochloric Acid SCHEMBL842371 0.93 CDK2 (0.37) CDK2CDK8CDK1UBE2MDCUN1D1
Hydrochloric Acid SCHEMBL842650 0.93 CDK2 (0.37) CDK2CDK8CDK1UBE2MDCUN1D1
SCHEMBL2250085 0.93 UBE2M (0.38) CDK2CDK8CDK1UBE2MDCUN1D1
SCHEMBL2255260 0.93 CDK2 (0.36) CDK2CDK8CDK1UBE2MDCUN1D1
SCHEMBL2256696 0.93 UBE2M (0.39) CDK2CDK8CDK1UBE2MDCUN1D1
SCHEMBL2254214 0.93 CDK2 (0.36) CDK2CDK8CDK1UBE2MDCUN1D1
SCHEMBL2253885 0.92 CDK2 (0.37) CDK2CDK8CDK1UBE2MDCUN1D1
SCHEMBL2252443 0.91 UBE2M (0.37) CDK2CDK8CDK1UBE2MDCUN1D1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2009058919-A1 CCR5 ANTAGONISTS AS THERAPEUTIC AGENTS SMITHKLINE BEECHAM CORPORATION (US) 2009-05-07 WO claimed
WO-2009058919-A1 CCR5 ANTAGONISTS AS THERAPEUTIC AGENTS SMITHKLINE BEECHAM CORPORATION (US) 2009-05-07 WO disclosed
WO-2009058919-A1 CCR5 ANTAGONISTS AS THERAPEUTIC AGENTS SMITHKLINE BEECHAM CORPORATION (US) 2009-05-07 WO disclosed