Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 3/20 | 0.41 |
| ▸ | ESR1 | P03372 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.33 |
| ▸ | HSD11B2 | P80365 | 1/20 | 0.32 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4083858 | 0.88 | ESR1 (0.36) | HSD11B1ESR1CYP2C9ESR2HSD11B2 | |
| SCHEMBL4078831 | 0.86 | HSD11B1 (0.39) | HSD11B1HSD11B2 | |
| SCHEMBL4079016 | 0.83 | HSD11B1 (0.35) | HSD11B1ESR1CYP2C9ESR2HSD11B2 | |
| SCHEMBL74426 | 0.78 | HSD11B1 (0.41) | HSD11B1ESR1CYP2C9ESR2EPHX2 | |
| SCHEMBL4078906 | 0.74 | HSD11B1 (0.40) | HSD11B1HSD11B2 | |
| SCHEMBL4082488 | 0.74 | HSD11B1 (0.39) | HSD11B1HSD11B2 | |
| SCHEMBL4078865 | 0.72 | HSD11B1 (0.45) | HSD11B1HSD11B2 | |
| SCHEMBL4082564 | 0.70 | HSD11B1 (0.44) | HSD11B1 | |
| SCHEMBL4088681 | 0.69 | HSD11B1 (0.43) | HSD11B1 | |
| SCHEMBL4088080 | 0.69 | CHRNA1 (0.37) | HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2104665-A2 | IMIDAZOLONE AND IMIDAZOLIDINONE DERIVATIVES AS 11B-HSD1 INHIBITORS FOR DIABETES | F. Hoffmann-Roche AG (CH) | 2009-09-30 | — | — | EP | claimed |
| WO-2008046758-A2 | IMIDAZOLONE AND IMIDAZOLIDINONE DERIVATIVES AS 11B-HSD1 INHIBITORS FOR DIABETES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-04-24 | — | — | WO | claimed |
| EP-2104665-A2 | IMIDAZOLONE AND IMIDAZOLIDINONE DERIVATIVES AS 11B-HSD1 INHIBITORS FOR DIABETES | F. Hoffmann-Roche AG (CH) | 2009-09-30 | — | — | EP | disclosed |
| WO-2008046758-A2 | IMIDAZOLONE AND IMIDAZOLIDINONE DERIVATIVES AS 11B-HSD1 INHIBITORS FOR DIABETES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-04-24 | — | — | WO | disclosed |