Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.49 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.42 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.42 |
| ▸ | CCR2 | P41597 | 4/20 | 0.42 |
| ▸ | F13A1 | P00488 | 1/20 | 0.42 |
| ▸ | TGM2 | P21980 | 1/20 | 0.42 |
| ▸ | TGM1 | P22735 | 1/20 | 0.42 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.40 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | AR | P10275 | 1/20 | 0.37 |
| ▸ | SPR | P35270 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | PREP | P48147 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5981386 | 1.00 | HSD11B1 (0.49) | HSD11B1CHRM2CHRM1CHRM3CCR2 | |
| SCHEMBL16317835 | 0.85 | TSHR (0.44) | HSD11B1CHRM2CHRM1CHRM3CCR2 | |
| SCHEMBL29333694 | 0.83 | HSD11B1 (0.44) | HSD11B1CHRM2CHRM1CHRM3CCR2 | |
| SCHEMBL30365145 | 0.83 | HSD11B1 (0.51) | HSD11B1CHRM2CHRM1CHRM3CCR2 | |
| SCHEMBL21577700 | 0.83 | HSD11B1 (0.51) | HSD11B1CHRM2CHRM1CHRM3CCR2 | |
| SCHEMBL1197096 | 0.83 | HSD11B1 (0.51) | HSD11B1CHRM2CHRM1CHRM3CCR2 | |
| SCHEMBL24402946 | 0.81 | HSD11B1 (0.50) | HSD11B1CHRM2CHRM1CHRM3CCR2 | |
| SCHEMBL18701744 | 0.81 | HSD11B1 (0.50) | HSD11B1CHRM2CHRM1CHRM3CCR2 | |
| SCHEMBL10061478 | 0.81 | HSD11B1 (0.50) | HSD11B1CHRM2CHRM1CHRM3CCR2 | |
| SCHEMBL10201870 | 0.81 | HSD11B1 (0.50) | HSD11B1CHRM2CHRM1CHRM3CCR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090149468-A1 | Substituted heterocyclic compounds and methods of use | AMGEN INC. (US) | 2009-06-11 | — | — | US | disclosed |
| US-7176210-B2 | Cannabinoid receptor ligands and uses thereof | PFIZER INC. (US) | 2007-02-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090149468-A1 | Substituted heterocyclic compounds and methods of use | HLA-DRB1, PRKDC, NFATC1 | HSD11B1 1378/4885CHRM2 642/4885CHRM1 468/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.