⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18799918 | 0.61 | — | — | |
| SCHEMBL13299988 | 0.60 | ADORA2A (0.33) | — | |
| SCHEMBL33726 | 0.60 | — | — | |
| SCHEMBL219198 | 0.59 | — | — | |
| SCHEMBL12432551 | 0.50 | — | — | |
| SCHEMBL12432547 | 0.49 | — | — | |
| SCHEMBL10414868 | 0.49 | NQO1 (0.50) | — | |
| SCHEMBL34472783 | 0.48 | LMNA (0.58) | — | |
| SCHEMBL2643813 | 0.48 | LMNA (0.50) | — | |
| SCHEMBL12432545 | 0.46 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1963328-B1 | INHIBITORS OF CYSTEINE PROTEASES, THE PHARMACEUTICAL COMPOSITIONS THEREOF AND THEIR THERAPEUTIC APPLICATIONS | HYBRIGENICS SA (FR) | 2013-10-30 | — | — | EP | disclosed |
| US-20090181972-A1 | Novel Inhibitors of Cysteine Proteases, the Pharmaceutical Compositions Thereof and their Therapeutic Applications | HYBRIGENICS SA (FR) | 2009-07-16 | — | — | US | disclosed |
| US-7462615-B2 | Inhibitors of cysteine proteases, the pharmaceutical compositions thereof and their therapeutic applications | HYBRIGENICS SA (FR) | 2008-12-09 | — | — | US | disclosed |
| EP-1963328-A2 | INHIBITORS OF CYSTEINE PROTEASES, THE PHARMACEUTICAL COMPOSITIONS THEREOF AND THEIR THERAPEUTIC APPLICATIONS | Hybrigenics S.A. (FR) | 2008-09-03 | — | — | EP | disclosed |
| EP-1798232-A1 | Inhibitors of cysteine proteases, the pharmaceutical compositions thereof and their therapeutic applications | Hybrigenics S.A. (FR) | 2007-06-20 | — | — | EP | disclosed |
| EP-1798232-A1 | Inhibitors of cysteine proteases, the pharmaceutical compositions thereof and their therapeutic applications | Hybrigenics S.A. (FR) | 2007-06-20 | — | — | EP | disclosed |
| WO-2007066200-A2 | INHIBITORS OF CYSTEINE PROTEASES, THE PHARMACEUTICAL COMPOSITIONS THEREOF AND THEIR THERAPEUTIC APPLICATIONS | HYBRIGENICS SA (FR) | 2007-06-14 | — | — | WO | disclosed |
| WO-2007066200-A2 | INHIBITORS OF CYSTEINE PROTEASES, THE PHARMACEUTICAL COMPOSITIONS THEREOF AND THEIR THERAPEUTIC APPLICATIONS | HYBRIGENICS SA (FR) | 2007-06-14 | — | — | WO | disclosed |
| US-20070135439-A1 | Novel inhibitors of cysteine proteases, the pharmaceutical compositions thereof and their therapeutic applications | HYBRIGENICS SA (FR) | 2007-06-14 | — | — | US | disclosed |