Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 1/20 | 0.43 |
| ▸ | IKBKB | O14920 | 1/20 | 0.43 |
| ▸ | PI4KA | P42356 | 1/20 | 0.42 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.42 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.42 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.42 |
| ▸ | BTK | Q06187 | 1/20 | 0.42 |
| ▸ | SRC | P12931 | 5/20 | 0.42 |
| ▸ | HTR2A | P28223 | 3/20 | 0.38 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.38 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.37 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.37 |
| ▸ | XDH | P47989 | 1/20 | 0.37 |
| ▸ | ABL1 | P00519 | 3/20 | 0.37 |
| ▸ | EGFR | P00533 | 3/20 | 0.37 |
| ▸ | ABL2 | P42684 | 3/20 | 0.37 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.37 |
| ▸ | FFAR2 | O15552 | 2/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19230428 | 0.88 | BTK (0.56) | BTKSRCTNK2 | |
| SCHEMBL8819946 | 0.86 | BTK (0.43) | HTR6IKBKBPI4KAPI4K2BPI4K2A | |
| SCHEMBL8819702 | 0.80 | EGFR (0.41) | PI4KAPI4K2BPI4K2API4KBBTK | |
| SCHEMBL5250649 | 0.76 | TNK2 (0.47) | BTKSRCEGFRTNK2KDR | |
| SCHEMBL23847508 | 0.75 | TNK2 (0.48) | BTKSRCEGFRTNK2KDR | |
| SCHEMBL28645873 | 0.74 | SLC6A4 (0.40) | BTKHTR2ARPS6KB1EGFRHTR2C | |
| SCHEMBL29989219 | 0.74 | SLC6A4 (0.40) | BTKHTR2ARPS6KB1EGFRHTR2C | |
| SCHEMBL21044835 | 0.69 | BTK (0.73) | BTKEGFRTNK2 | |
| SCHEMBL8819471 | 0.69 | PI4KA (0.46) | PI4KAPI4K2BPI4K2API4KBSRC | |
| SCHEMBL23834462 | 0.69 | BTK (0.45) | BTKTNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120065201-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | PHARMACYCLICS, INC. (US) | 2012-03-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120065201-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | ABL1, BTK, ABL2 | HTR6 4681/4885IKBKB 349/4885PI4KA 678/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.